Pseudorabies virus mutants, vaccines containing same, methods fo

Details Pseudorabies virus mutants, vaccines containing same, methods fo Pseudorabies virus mutants, vaccines containing same, methods fo

1987-09-10

1988-06-28

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

435 68, 4351723, 435236, 4351721, 935 65, 424 89, C12N 704, C12N 1500, C12P 2100, A61K 39245

Patent

active

047538848

ABSTRACT:
The present invention relates to pseudorabies virus mutants containing deletion and/or insertion mutations in a major viral glycoprotein gene, such that no antigenic polypeptides encoded by the viral gene are produced. As a result, animals vaccinated with such do not develop antibodies to the viral glycoprotein and can be distinguished from animals infected with pseudorabies virus field strains and known pseudorabies virus vaccine strains. The present invention also relates to vaccines for pseudorabies disease containing the same, methods for production of the same and methods for use of the same.

REFERENCES:
patent: 4514497 (1985-04-01), Kit et al.
Robbins et al. (1984), J. Molecular and Applied Genetics, vol. 2, pp. 485-496.
Mettenleiter et al. (1985), J. of Virology, vol. 56, pp. 307-311.
Lomniczi et al. (1984), J. of Virology, vol. 52, pp. 198-205.
Lee et al. (1982), Proc. Natl. Acad. Sci. USA, vol. 79, pp. 6612-6616.
Maes et al (1983), J. of Veterinary Research, vol. 44 pp. 123-125.
Reed (1982), 48th Annual Meeting, Ill. Vet. Med. Assoc.

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