Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...
Patent
1986-01-28
1987-12-08
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
435236, 435 68, 4351721, 4351723, 424 89, C12N 700, A61K 39205
Patent
active
047118504
ABSTRACT:
The present invention relates to pseudorabies virus mutants containing deletion and/or insertion mutations in a major viral glycoprotein gene, such that no antigenic polypeptides encoded by the viral gene are produced. As a result, animals vaccinated with such do not develop antibodies to the viral glycoprotein and can be distinguished from animals infected with pseudorabies virus field strains and known pseudorabies virus vaccine strains. The present invention also relates to vaccines for pseudorabies disease containing the same, methods for production of the same and methods for use of the same.
REFERENCES:
patent: 4514497 (1985-04-01), Kit et al.
Robbins et al., (1984), J. Molecular and Applied Genetics, vol. 2, pp. 485-496.
Methenleiter et al., (1985), J. of Virology, vol. 56, pp. 307-311.
Lomniczi et al., (1984), J. Of Virology, vol. 52, pp. 198-205.
Lee et al., (1982), Proc. Nat'l. Acad. Sci. U.S.A., vol. 79, pp. 6612-6616.
Macs et al., (1983), J. of Vetinary Rev., vol. 44, pp. 123-125.
Reed, (1982), 48th Annual Mtg., Ill. Vet. Med. Assoc.
Kit Malon
Kit Saul
Baylor College of Medicine
Novagene Inc.
Seidman S.
Wiseman Thomas G.
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