Pseudopterosin and synthetic derivatives thereof

Details Pseudopterosin and synthetic derivatives thereof Pseudopterosin and synthetic derivatives thereof

1987-08-14

1989-07-18

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 181, A61K 3170, C07H 1524

Patent

active

048494100

ABSTRACT:
Methods for treating mammals to reduce pain, reduce cell proliferation and/or reduce inflammation are described based on administering to the mammals compounds having the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen or an acyl group having from 1 to 6 carbon atoms; R.sub.5 is hydrogen, CH.sub.3 or CH.sub.2 OH and R.sub.6 is a hydrocarbon having from 1 to 10 carbon atoms. Natural and synthetic 1,12-seco derivatives with similar utilities are disclosed. Natural and synthetic derivatives are also disclosed where the sugar moiety is attached at the C-10 carbon on the tricyclic diterpene moiety instead of the C-9 carbon.

REFERENCES:
patent: 4447445 (1984-05-01), Manoalide
patent: 4521592 (1985-06-01), Dahmen et al.
Johnson et al., Cancer Treatment Reviews (1975), vol. 2, pp. 1-31.
Look, S. A., Studies of the Natural Products Chemistry of Selected Carribean Gorgonians, Ph.D. Dissertation, University of California (1983).

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