Pseudopeptide isosteres of gly-asp and their use as antithrombic

Details Pseudopeptide isosteres of gly-asp and their use as antithrombic Pseudopeptide isosteres of gly-asp and their use as antithrombic

1994-03-01

1996-10-01

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 530331, A61K 3805

Patent

active

055611125

ABSTRACT:
Pseudopeptides of formula I in free or salt form ##STR1## wherein A, B, R.sub.1, X, Y and m are defined as in claim 1, and their use in the prophylactic and acute treatment of thrombosis.

REFERENCES:
patent: 4578079 (1986-03-01), Ruoslahti et al.
patent: 5273982 (1993-12-01), Alig
patent: 5354738 (1994-10-01), Tjoeng
The Journal of Biological Chemistry vol. 268, No. 9, Issue of Mar. 25, 1993 pp. 6800-6808.
The Journal of Biological Chemistry vol. 268, No. 7, Issue of Mar. 5, 1993 pp. 4734-4741.
Thrombosis and Haemostasis 70 (3) 531-539 (1993).
Thrombosis and Haemostasis 70 (5) 838-847 (1993).
European Search Report.

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