Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1991-01-04
1996-02-27
Sidberry, Hazel F.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4242421, 4241841, 4241851, 530326, 530327, 530328, A61K 3800, A61K 3804, A61K 39104, A61K 3902
Patent
active
054946727
ABSTRACT:
A peptide having a sequence corresponding to a C-terminal portion of the Pseudomonas aeruginosa pilin protein is disclosed. The peptide is cross-reactive with surface peptides present in certain bacterial and fungal microorganisms, and is effective in inhibiting binding of such organisms to target epithelial cells. The peptide may also be employed in a vaccine composition, for producing immunity against such cross-reactive microorganisms. Also disclosed are methods of preparing peptides which are cross-reactive with the P. aeruginosa pilin peptide, and chimeric monoclonal antibodies immunoreactive with the pilin peptide.
REFERENCES:
patent: 4745055 (1988-05-01), Schenk et al.
Doig, P. et al., Can. J. Microbiol., (1986) 32:160-166.
Doig, P. et al., Infect. Immun., (1987) 55(6):1517-1522.
Doig, P. et al., Infect. Immun., (1988) 56(6):1641-1646.
Doig, P. et al., Can J. Microbiol., (1989) 35:1141-1145.
Doig, P. et al., Infect. Immun. (1990) 58(1):124-130.
Franklin, A. L. et al., Infect. Immun., (1987) 55(6):1523-1525.
Irvin, R. T. et al., Infect. Immun., (1989) 57(12):3720-3726.
Irvin, R. T. et al., Microbiol. Ecology Health Disease, (1990) 3:39-47.
Irvin, R. T. in "Microbial Cell Surface Hydrophobicicy", Chapter 5 (1990) (R. J. Doyle & M. Rosenberg, Eds.) 137-177.
Lee, K. K. et al., Molecular Microbiology, (1989) 3(11):1493-1499.
Lee, K. K. et al., Infect. Immun., (1989) 57(2):520-526.
Locht, C. & Kieth, J. M., Science, (Jun. 6, 1986) 232(4755):1258-1264.
Paranchych, W., et al., Antibiot. Chemother., 36:49-57.
Sastry, P. A., et al., J. Bacteriology (Nov. 1985) 164(2):571-577.
Sastry, P. A., et al., Can. J. Cell. Biol. (1985) 63:284-291.
Sastry, L., et al., Proc. Natl. Acad. Sci. U.S.A. (1989) 865728-5732.
Saiman, L., et al., Infect. Immun., (1989) 57(9):2764-2770.
Sato, H. & Okinaga, K., Infect. Immun., (1987) 55(8):1774-1778.
Staddon, W., et al., Can. J. Microbiol. (1990) 36:336-339.
Smart, W., et al., Infect. Immun., (1988) 56(1):18-23.
Watts, T. H., et al., Infect. Immun., (1983) 42(1):113-121.
Doig Peter C.
Hodges Robert S.
Irvin Randall T.
Lee Kok K.
Paranchych William
Dehlinger Peter J.
S.P.I. Synthetic Peptides Incorporated
Sidberry Hazel F.
Stratford Carol A.
LandOfFree
Pseudomonas peptide composition and method does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pseudomonas peptide composition and method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pseudomonas peptide composition and method will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1677096