Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1991-04-24
1993-09-14
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
436513, 530413, 530825, C07L 302, C07K 320, C07K 1504
Patent
active
052450163
ABSTRACT:
A protein isolated from Pseudomonas maltophilia is found to possess an exposed, immunologically accessible protein which binds to the FC region of several species of immunoglobulins. The protein is found to bind both IgG and IgA immunoglobulins and is found to have an effective molecular weight of approximately 30,000 daltons. The protein is found to be useful in isolation of IgA immunoglobulins from biological mixtures. The protein makes IgA immunoglobulins available for further analytical techniques, including identifying bacteria which contain IgA binding proteins. Because of the increased availability of IgA immunoglobulins, it is possible to diagnosis and treat IgA-related diseases and their sources.
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This invention was made with government support under Grant No. R01-HD18986-04 awarded by the Department of Health and Human Services/Institutes of Health. The government has certain rights in the invention.
Grover Sanjeev
McGee Zeil A.
Odell William D.
Russel Jeffrey E.
University of Utah Research Foundation
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