Pseudomonas exotoxins (PE) and conjugates thereof having lower a

Details Pseudomonas exotoxins (PE) and conjugates thereof having lower a Pseudomonas exotoxins (PE) and conjugates thereof having lower a

1993-10-01

1996-04-30

Lacey, David L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

4241831, 4242361, 4242601, 435 697, 435 713, 435875, 435 691, 935 11, 5303873, 5303917, C12N 1531, C07K 1421, A61K 3904

Patent

active

055126588

ABSTRACT:
Improved Pseudomonas exotoxins of low animal toxicity and high cytocidal activity are described. Substitution of positively charged amino acid residues with an amino acid residue without a positive charge provides markedly changed exotoxins. Conjugation of the new exotoxins with suitable targeting agents provides cytocidal specificity for killing desired cellular entities.

REFERENCES:
patent: 4545985 (1985-10-01), Pastan et al.
patent: 4892827 (1990-01-01), Pastan et al.
Siegall et al PNAS 85: 9738-9742 (1988) Cytotoxic Activity . . . of 1L6-PE fusion protein.
Munro Cell 48: 899-907 (1987) C terminal signal prevents secretion . . . .
Chaudhary Nature (1988) Chaudhary (PNAS) 87:302-312 (1990).
Pastan PNAS (84) 4538-4542 (1987).
Allured, Viloya, S., et al., "Structure of exotoxin A of Pseudomonas aeruginosa at .cedilla.ngstrom resloution", Proc. Natl. Acad. Sci. USA, vol. 83, pp. 1320-1324, Mar. 1986.
Chaudhary et al., Proc. Nat'l Acad. Sci USA Genetics, vol. 84, Jul., 1987 pp. 4538-4542.
Siegall et al; J. of Biological Chemistry, vol. 264, No. 24, Aug., 1989, pp. 14256-14261.
Chaudhary et al., Proc. Nat'l. Acad Sci USA, vol. 07, Jan. 1990, pp. 300-312.
Munro et al, Cell, vol. 48, Mar., 1987, pp. 899-907.
Chow et al, J. of Biol. Chem., vol. 264, NO. 31, Nov., 1989, pp. 18818-18823.
Waldmann, J. of Nat'l Cancer Inst., vol. 81, No. 12, Jun., 1909, pp. 919-923.
Lorberboum-Galski, Proc. Nat'l. Acad. Sci USA, vol. 86, Feb., 1989, pp. 1008-1012.
Lorberboum-Galski, J. of Biol. Chem., vol. 263, No. 35, Dec., 1988, pp. 18650-18656.
Lorberboum-Galski, Proc. Nat'l Acad. Sci USA, vol. 85, Mar., 1988, pp. 1922-1926.
Bailon et al., Biotechnology, Nov., 1988, pp. 1326-1329.
Ogata et al., J. of Immunology, vol. 141, No. 12, Dec., 1988, pp. 4224-4228.
Case et al., Proc. Nat'l Acad. Sci USA, vol. 86, Jun., 1909, pp. 281-291.
Siegall et al., Proc. Nat'l. Acad. Sci. USA, vol. 85, Dec. 1988, pp. 9738-9742.
Chaudhary et al., Nature, 1988.
Hwang et al., Cell, Jan., 1987.

Affiliated with

Also associated with

Rating

Pseudomonas exotoxins (PE) and conjugates thereof having lower a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pseudomonas exotoxins (PE) and conjugates thereof having lower a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pseudomonas exotoxins (PE) and conjugates thereof having lower a will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-629735