Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1984-01-26
1985-10-08
Wiseman, Thomas G.
Drug, bio-affecting and body treating compositions
Lymphokine
424 88, 424 92, 514 2, 514 6, 260112B, 260112R, A61K 3900, A61K 3902, A61K 3700, A23J 106
Patent
active
045459851
ABSTRACT:
A method of modifying Pseudomonas exotoxin (PE) with methyl-4-mercaptobutyrimidate is disclosed so that after conjugating the exotoxin to a monoclonal antibody (ab) such as the antibody to the transferrin receptor, the PE-ab conjugate becomes a highly potent immunotoxin suitable for use against human tumor cells. This same method has been used to conjugate PE to epidermal growth factor (EGF) to create a highly potent growth factor-toxin conjugate for use against cells having large numbers of EGF receptors. Also disclosed are the immunotoxin conjugates for Pseudomonas exotoxin coupled to anti-TFR (antibody to the transferrin receptor) and anti-TAC (antibody to the human T-cell growth factor receptor) and to EGF.
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Fitzgerald David J.
Pastan Ira
Willingham Mark C.
Roberts, Jr. John S.
Teskin Robin
The United States of America as represented by the Secretary, De
Wiseman Thomas G.
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