Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 11 to 14 amino acid residues in defined sequence
Patent
1991-06-25
1993-06-29
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
11 to 14 amino acid residues in defined sequence
530326, 530300, 424 92, A61K 3902, A61K 3702, C07K 700, C07K 1500
Patent
active
052236048
ABSTRACT:
A peptide having a sequence corresponding to an antigenic site in the protein exoenzyme S which is antigenically similar to a C-terminal portion of the Pseusdomonas aeruginosa pilin protein is disclosed. The peptide is cross-reactive with surface peptides present in certain bacterial and fungal microorganisms, and is effective in inhibiting binding of such organisms to target epithelial cells. The peptide may also be employed in a vaccine composition, for producing immunity against such cross-reactive microorganisms.
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Hodges Robert S.
Irvin Randall T.
Paranchych William
Sokol Pamela A.
Woods Donald E.
Dehlinger Peter J.
Nucker Christine M.
S.P.I. Synthetic Peptides Incorporated
Sidberry Hazel F.
Stratford Carol A.
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