Pseudo native chemical ligation

Details Pseudo native chemical ligation Pseudo native chemical ligation

2006-04-18

2006-04-18

Russel, Jeffrey Edwin (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

C530S300000, C530S345000, C530S350000, C530S351000, C530S399000

Reexamination Certificate

active

07030218

ABSTRACT:
The present invention concerns methods and compositions for extending the technique of native chemical ligation of a wider range of peptides, polypeptides, other polymers and other molecules via an amide bond (see FIG.1). The invention further provides methods and uses for such proteins and derivatized proteins. The invention is particularly suitable for use in the synthesis of optionally polymer-modified, synthetic bioactive proteins, and of pharmaceutical compositions that contain such proteins.

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