Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.
Patent
1995-03-09
1998-10-06
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Tripeptides, e.g., tripeptide thyroliberin , etc.
530330, 514 17, 514 18, A61K 3806
Patent
active
058177566
ABSTRACT:
The invention provides bradykinin antagonist compounds wherein many (or all) of the peptide bonds of bradykinin are eliminated to yield compounds which specifically compete with bradykinin for binding to the bradykinin receptor. More particularly, the invention relates to compounds having, in appropriate spatial arrangement, two positively charged moieties flanking a hydrophobic organic moiety and a moiety which mimics a beta turn conformation.
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Chakravarty Sarjavit
Kyle Donald James
Lu Zhijian
Mavunkel Babu Joseph
Jarvis Marjorie L.
Lukton David
Scios Inc.
Shearer Peter R.
Tsang Cecilia J.
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