PSA positive regulating (PSAR) sequences and uses thereof

Details PSA positive regulating (PSAR) sequences and uses thereof PSA positive regulating (PSAR) sequences and uses thereof

1997-03-27

2000-08-29

Eyler, Yvonne

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 701, 4353201, 435455, 435466, 536 241, C12P 2106, C12P 2104, C12N 1500, C07H 2104

Patent

active

061107026

ABSTRACT:
The present invention provides an isolated nucleic acid molecule which is a PSA positive regulatory sequence (PSAR). This molecule has been deposited with the ATCC. In one embodiment of the invention, the molecule comprises a nucleic acid sequence shown in FIG. 4 (SEQ ID NO: 3).

REFERENCES:
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Pang, S. et al., "Identification of a Positive Regulatory Element Responsible for Tissue-specific Expression of Prostate-specific Antigen," Cancer Research, 57:459-499, Feb. 1, 1997. (Exhibit 2).
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Cleutjens, Kitty B.J.M. et al., "An Androgen Response Element in a Far Upstream Enhancer Region Is Essential for High, Androgen-Regulated Activity of the Prostate-specific Antigen Promoter," Molecular Endocrinology, 11(2):148-161, 1997. (Exhibit 4).
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