Protozoan strains of reduced virulence and use thereof

Details Protozoan strains of reduced virulence and use thereof Protozoan strains of reduced virulence and use thereof

2004-10-25

2010-06-08

Duffy, Patricia A (Department: 1645)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Protozoa, media therefor

C424S269100

Reexamination Certificate

active

07732188

ABSTRACT:
The present invention relates to a protozoan strain of the family of the Trypanosomatidae the virulence of which is lower than that of the corresponding wild-type strain, characterized in that at least one copy of the SIR2 gene present in the genome of the strain is inactivated.

REFERENCES:
patent: 6248329 (2001-06-01), Chandrashekar et al.
patent: 2002/0177697 (2002-11-01), Fasel et al.
Ellis, R.W. (Chapter 29 of “Vaccines” [Plotkin, S.A. et al. (eds) published by W. B. Saunders company (Philadelphia) in 1988, especially p. 571, 2nd full paragraph].
Cordeiro-Da-Silva A et al: “Identification of antibodies to Leishmania silent information regulatory 2 C SIR2 ) protein homologue during canine natural infections: pathological implications.” Immunology Letters, (Apr. 3, 2003) 86 (2) 155-62., Apr. 2003, XP001181346, the whole document.
Titus R G et al: “Development of a Safe 1-14 Live Leishmania Vaccine Line by Gene Replacement” Proceedings of the National Academy of Sciences of USA, National Academy of Science. Washington, US, vol. 92, Oct. 1995, pp. 10267-10271, XP002052134, ISSN: 0027-8424 cited in the application, the whole document.
Garcia-Salcedo Jose A et al: “A chromosomal SIR2 homologue with both hi stone NAD-dependent ADP-ri bosyltransferase and deacetyl ase activities is involved in DNA repair in Trypanosoma brucei .” EMBO Journal, (Nov. 3, 2003) 22 (21) 5851-62., Nov. 2003, XP002281455.
Vergnes Baptiste et al: “Cytoplasmic SIR2 homologue overexpression promotes survival of Leishmania parasites by preventing programmed cell death.” Gene, (Aug. 21, 2002) 296 (1-2) 139-50., Aug. 2002, XP004386950, cited in the application.

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