Proton pump inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S423000, C514S424000, C548S541000, C548S531000

Reexamination Certificate

active

08048909

ABSTRACT:
A proton pump inhibitor containing a compound represented by the formula (I)wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main chain, R1is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R2, R3and R4are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted thienyl group, an optionally substituted benzo[b]thienyl group, an optionally substituted furyl group, an optionally substituted pyridyl group, an optionally substituted pyrazolyl group, an optionally substituted pyrimidinyl group, an acyl group, a halogen atom, a cyano group or a nitro group, R5and R6are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, which has a superior proton pump action and shows an antiulcer activity and the like after conversion to a proton pump inhibitor in the body, or a salt thereof, or a prodrug thereof is provided.

REFERENCES:
patent: 5286742 (1994-02-01), Henegar et al.
patent: 5480902 (1996-01-01), Addor et al.
patent: 6365620 (2002-04-01), Eberle et al.
patent: 2002/0193410 (2002-12-01), Burns et al.
patent: 0259085 (1988-03-01), None
patent: 0464845 (1992-01-01), None
patent: 0538231 (1993-04-01), None
patent: 0597291 (1994-05-01), None
patent: 1061075 (2000-12-01), None
patent: 1284260 (2001-05-01), None
patent: 1176139 (2002-01-01), None
patent: 1432693 (2004-06-01), None
patent: 1466902 (2004-10-01), None
patent: 1477489 (2004-11-01), None
patent: 1655284 (2006-05-01), None
patent: 63-63678 (1988-03-01), None
patent: 08-119936 (1996-05-01), None
patent: 09-030967 (1997-02-01), None
patent: 9-30967 (1997-02-01), None
patent: 11-209344 (1999-08-01), None
patent: 2004-315511 (2004-11-01), None
patent: WO-92/04025 (1992-03-01), None
patent: WO-93/09100 (1993-05-01), None
patent: WO-98/08815 (1998-03-01), None
patent: WO-98/28269 (1998-07-01), None
patent: WO-00/58285 (2000-10-01), None
patent: WO-02/02524 (2002-01-01), None
patent: WO-02/02554 (2002-01-01), None
patent: WO-03/028641 (2003-04-01), None
patent: WO-03/040147 (2003-05-01), None
patent: WO-03/044011 (2003-05-01), None
patent: WO-03/068738 (2003-08-01), None
patent: WO-03/068740 (2003-08-01), None
patent: WO-03/070729 (2003-08-01), None
patent: WO-03/106427 (2003-12-01), None
patent: WO-2004/014368 (2004-02-01), None
patent: WO-2004/103968 (2004-12-01), None
Banker et al, “Modern Pharmaceutics, 3ed.”, Marcel Dekker, New York, 1996, , pp. 451 and 596.
Wolff, Manfred E. “Burger's Medicinal Chemistry, 5ed, Part I”, John Wiley & Sons, 1995, pp. 975-977.
Merck Manual about stomach cancer, Dec. 2007.
P. W. Shum, “A convenient method for the synthesis of unsymmetrical 3,4-disbustituted pyrroles,” Tetrahedron Letters, vol. 31, No. 47, pp. 6785-6788 (1990).
P. W. Shum et al., “A Convenient Method for the Synthesis of Unsymmetrical 3,4-Disubstituted Pyrroles,”Tetrahedron Letters, vol. 31, No. 47, pp. 6785-6788 (1990).
K. Okabe et al., “The Second Generation Synthesis of a Tumor Promoter Pendolmycin,”Tetrahedron, vol. 47, No. 37, pp. 7615-7624 (1991).
Attanasi, Orazio, et al.: “Effect of Metal Ions in Organic Synthesis; XVIII. A Simple and High-Yield Direct Synthesis of 1-Arylamino-3-aminocarbonylpyrroles by the Copper(II) Chloride-Catalyzed Reaction of Arylazoalkenes with 3-Oxoalkanamides,” Synthesis, vol. 1983, No. 9, 1983, pp. 742-744, XP002544392.
Attanasi, Orazio, et al: “Effect of Metal Ions in Organic Synthesis; Part XXIII. Easy and High-Yield Direct Synthesis of 3-Aminocarbonyl-1-ureidopyroles by the Copper (II) Chloride-Catalyzed Reaction of 3-Oxoalkanamides” Synthesis, vol. 1984, No. 8, 1984, pp. 671-672, XP002544393 *the whole document*.
Attanasi, Orazio, et al: “Effect of Metal Ions in Organic Synthesis; Part XXIV. Facile One-Flask Synthesis of 1-Alkoxycarbonylamino-3-aminocarbonylpyrro Ies by Reaction of Alkoxycarbonylazoalkenes with 3-Oxoalkanamides under Copper(II) Chloride Catalysis” Synthesis, vol. 1984, No. 10, 1984, pp. 873-874, XP002544394 *the whole document *.
Artico, Marino, et al: “Structure-Based Design, Synthesis, and Biological Evaluation of Novel Pyrrolyl Aryl Sulfones: HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors Active at Nanomolar Concentrations,” J. Med. Chem., vol. 43, 2000, pp. 1886-1891, XP002544396.
European Search Report for Corresponding European Application No. EP 05 79 0387 completed on Sep. 17, 2009.
R. Scott Obach: “Drug-Drug Interactions: An Important Negative Attribute in Drugs”, Drugs of Today, 2003, 39(5): 301-338.
Barry M. Trost, et al.: “A [3 + 2] and [4 + 3] Cycloaddition Approach to N-Heterocycles via Pd-Catalyzed TMM Reactions with Imines”, J. Am. Chem. Soc. 1993, 115, 6636-6645.
Barry M. Trost, et al: “A selectivity control element for palladium-catalyzed trimethylenemethane cycloaddition”, J. Am. Chem. Soc. 1991, 113 (23), 9007-9009.
Sergej N. Osipov, et al: “A radical pathway to α-difluoromethylene containing prolines and α-aminoadipic acids”, Tetrahedron Letters 41 (2000) 5659-5662.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Proton pump inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Proton pump inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Proton pump inhibitors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4296159

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.