Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-05-30
1998-01-13
Walsh, Stephen
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 691, 530395, C07K 14435, C12N 1512
Patent
active
057081433
ABSTRACT:
Polynucleotide sequences encoding novel cadherin-like polypeptides, designated protocadherins, and variants thereof are provided by the invention as well as methods and materials for the recombinant production of the same. Antibody substances specific for protocadherins are also disclosed as useful for modulating the natural binding and/or regulatory activities of the protocadherins.
REFERENCES:
Sago et al., Genomics, 29, 631-640, 1995.
Amagai et al., "Autoantibodies against a Novel Epithelial Cadherin in Pemphigus Vulgaris, a Disease of Cell Adhesion", Cell, 67: 869-877 (Nov. 29, 1991).
Angerer et al., "Demonstration of Tissue-Specific Gene Expression of in Situ Hybridization", Methods of Enzymology, 152: 649-660, (1987).
Ausubel et al., Eds., Current Protocols in Molecular Biology, Sections 6.1.1 to 6.1.4 and 6.2.1 to 6.2.3, John Wiley & Sons, New York (1987).
Burt, "Morphologic Abnormalities in the Postnatal Differentiation of CA1 Pyramidal Cells and Granule Cells in the Hippocampal Formation of the Ataxic Mouse", Anat. Rec. 196: 61-69 (1980).
Chen et al., "Cell-Cell Contacts Mediated by E-Cadherin (Uvomorulin) Restrict Invasive Behavior of L-Cells:," J. Cell, Biol., 114(2): 319-327 (Jul. 1991).
Civitelli et al., "Connexin43 Mediates Direct Intercellular Communication in Human Osteoblastic Cell Networks", J. Clin. Invest., 91: 1888-1896 (1993).
Detrick et al., "The Effect of N-Cadherin Misexpression on Morphogenesis in Xenopus Embryos", Neuron, 4: 493-506 (Apr. 1990).
Donalies et al., "Expression of M-cadherin, a Member of the Cadherin Multigene Family, Correlates with Differentiation of Skeletal Muscle Cells", Proc. Natl. Acad. Sci. USA, 88: 8024-8028 (Sep. 1991).
Frixen et al., "E-Cadherin-Mediated Cell-Cell Adhesion Prevents Invasiveness of Human Carcinoma Cells" J. Cell. Biol., 113(1): 173-185 (Apr. 1991).
Fujimori et al., "Ectopic Expression of N-cadherin Perturbs Histogenesis in Xenopus Embryos", Development, 110: 97-104 (1990).
Gallin et al., "Sequence Analysis of a cDNA Clone Encoding the Liver Cell Adhesion Molecule, L-CAM", Proc. Natl. Acad. Sci. USA, 84: 2808-2812 (May 1987).
Goodwin et al., "Desmoglein Shows Extensive Homology to the Cadherin Family of Cell Adhesion Molecules", Biochem. Biophsy. Res. Commun., 173(3): 1224-1230 (Dec. 31, 1990).
Hatta et al., "Cloning and Expression of cDNA Encoding a Neural Calcium-dependent Cell Adhesion Molecule: Its Identity in the Cadherin Gene Family", J. Cell. Biol., 106: 873-881 (Mar. 1988).
Holton et al., "Desmosomal Glycoproteins 2 and 3 (desmocollins) Show N-terminal Similarity to Calcium-Dependent Cell-Cell Adhesion Molecules", J. Cell. Science, 97: 239-246 (1990).
Hynes et al., "Contact and Adhesive Specificities in the Associations, Migrations, and Targeting of Cells and Axons", Cell, 68: 303-322, (Jan. 24, 1992).
Inuzuka et al., "R-Cadherin: A Novel Ca.sup.2+ -Dependent Cell-Cell Adhesion Molecule Expressed in the Retina", Neruron, 7: 69-79 (1991).
Kennett, "Cell Fusion", Methods in Enzymol., 58: 345-359 (1979).
Kikuchi et al., "The Defective Organ of Corti in Shaker-1 Mice", Acta Oto-Laryng., 60: 287-303 (1965).
Kintner, "Regulation of Embryonic Cell Adhesion by the Cadherin Cytoplasmic Domain", Cell, 69: 225-236 (Apr. 17, 1992).
Koch et al., "Identification of Desmoglein, a Constitutive Desmosomal Glycoprotein, as a Member of the Cadherin Family of Cell Adhesion Molecules", Eur. J. Cell Biol., 53: 1-12 (1990).
Liaw et al., "Identification and Cloning of Two Species of Cadherins in Bovine Endothelial Cells", EMBO J., 9(9): 2701-2708 (1990).
Lord et al., "Shaker, A New Mutation of the House Mouse" (Mus Musculus) Am. Nat., 63: 453-442 (1929).
Lyon, M., "Twirler: A Mutant Affecting the Inner Ear of the House Mouse", J. Embryol. Exp. Morphol., 6: 105-116 (1958).
Lyon, M., "Ataxia--A New Recessive Mutant of the House Mouse", J. Hered., 46: 77-80 (1955).
Mahoney et al., "The fat Tumor Suppressor Gene in Drosophila Encodes a Novel Member of the Cadherin Gene Superfamily", Cell, 67: 853-868 (Nov. 29, 1991).
Maniatis et al., p. 196 in Molecular Cloning: A Laboratory Manual, Cold Spring Harbor, New York: Cold Spring Harbor Laboratory (1982).
Maruyama et al., "Detection of Calcium Binding Proteins by .sup.45 Ca Autoradiography on Nitrocellulose Membrane after Sodium Dodecyl Sulfate Gel Electrophoresis.sup.1 ", J. Biochem., 95: 511-519 (1984).
Matsunaga et al., "Guidance of Optic Nerve Fibers by N-cadherin Adhesion Molecules", Nature, 334: 62-64 (Jul. 1988).
Miyatani et al., "Neural Cadherin: Role in Selective Cell-Cell Adhesion", Science, 245: 631-635 (Aug. 1989).
Nagafuchi et al., "Transformation of Cell Adhesion Properties by Exogenously Introduced E-cadherin cDNA", Nature, 329: 341-343 (Sep. 1987).
Napolitano, et al., "Molecular Cloning and Characterization of B-Cadherin, a Novel Chick Cadherin", Cell Biol., 113(4): 893-905 (May 1991).
Nose et al., "Isolation of Placental Cadherin cDNA: Identification of a Novel gene Family of Cell-Cell Adhesion Molecules", EMBO J., 6(12): 3655-3661 (1987).
Porter et al., "Dystrophin Colocalizes with .beta.-Spectrin in Distinct Subsarcolemmal Domains in Mammalian Skeletal Muscle", J. Cell. Biol., 117(5): 997-1005 (Jun. 1992).
Pytela et al., "Polymerase Chain Reaction Cloning with Degenerate Primers: Homology-Based Identification of Adhesion Molecules", Methods in Enzymology, Erkki Ruoslahti and Eva Engvall, Eds., 245:420-451, Academic Press, (1994).
Ranscht et al., "T-Cadherin, a Novel Caherin Cell Adhesion Mol. in the Nervous System Lacks the Conserved Cytoplasmic Region", Neuron, 7: 391-402 (Sep. 1991).
Ringwald te al., "The Structure of Cell Adhesion Molecular Uvomorulin. Insights into the Molecular Mechanism of Ca.sup.2+ -Dependent Cell Adhesion", EMBO J., 6(12): 3647-3653 (1987).
Sano et al., "Protocadherins: A Large Family of Cadherin-Related Molecules in Central Nervous System", The EMBO Journal, 12(6): 2249-2256 (1993).
Seldon et al., "Genetic Analysis of Autoimmune gld Mice", J. Exp. Med., 167: 688-693 (1988).
Shimoyama et al., "Molecular Cloning of a Human Ca.sup.2+ -Dependent Cell-Cell Adhesion Molecule Homologous to Mouse Placental Cadherin: Its Low Expression in Human Placental Tissues", J. Cell. Biol., 109: 1787-1794 (Oct. 1989).
Suzuki et al., "Diversity of the Cadherin Family: Evidence for Eight New Cadherin in Nervous Tissue", Cell Regulation, 2: 261-270 (Apr. 1991).
Suzuki et al., "Evidence for Cadherin Superfamily" Cell Struc. Func., 16: 605 (Nov. 23, 1991).
Suzuki et al., "Evidence of Cadherin Superfamily" J. Cell. Biol., 115: 72(a) (Abstract 416) (Dec. 9, 1991).
Takeichi, "Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator.", Science, 251: 1451-1455 (Mar. 1991).
Takeichi, "Cadherins: A Molecular Family Important in Selective Cell-Cell Adhesion:", Annu. Rev. Biochem., 59: 237-252 (1990)
Thomas, "Hybridization of Denatured RNA and Small DNA Fragments Transferred to Nitrocellulose", Proc. Natl. Acad. Sci. USA, 77(9): 5201-5205 (Sep. 1980).
Towbin et al., "Electrophoretic Transfer of Proteins from Polyacrylamide Gels to Nitrocellulose Sheets: Procedure and Some Applications", PNAS 76: 4350-4354, (Sep. 1979).
Urushihara et al., "Immunological Detection of Cell Surface Components Related with Aggregation of Chinese Hamster and Chick Embryonic Cells", Dev. Biol., 70: 206-216 (1979).
Vandenbark et al., "Experimental Allergic Encephalomyelitis and Cellular Immunity in the Lewis Rat", Cell. Immunol., 12: 85-93 (1974).
Vleminckx et al., "Genetic Manipulation of E-Cadherin Expression by Epithelial Tumor Cells Reveals an Invasion Suppressor Role", Cell, 66: 107-119 (Jul. 12, 1991).
Doheny Eye Institute
Teng Sally P.
Walsh Stephen
LandOfFree
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