Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-05-30
1997-09-02
Walsh, Stephen
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530395, C07K 14705
Patent
active
056633009
ABSTRACT:
Polynucleotide sequences encoding novel cadherin-related polypeptides, designated protocadherins, and variants thereof are provided by the invention as well as methods and materials for the recombinant production of the same. Antibody substances specific for protocadherins are also disclosed as useful for modulating the natural binding and/or regulatory activities of the protocadherins.
REFERENCES:
Amagai et al., "Autoantibodies against a Novel Epithelial Cadherin in Pemphigus Vulgaris, a Disease of Cell Adhesion", Cell, 67: 869-877 (Nov. 29, 1991).
Angerer et al., "Demonstration of Tissue-Specific Gene Expression by in situ Hybridization", Methods in Enzymology, 152: 649-660 (1987).
Ausubel et al., Eds., Current Protocols in Molecular Biology, Sections 6.6.1-6.1.4, 6.2.1-6.2.3, John Wiley & Sons, New York (1987).
Chen et al., "Cell-Cell Contacts Mediated by E-Cadherin (Uvomorulin) Restrict Invasive behavior of L-Cells", J. Cell Biol., 114(2):319-327 (Jul. 1991).
Detrick et al., "The Effects of N-Cadherin Misexpression on Morphogenesis in Xenopus Embryos", Neuron, 4: 493-506 (Apr. 1990).
Donalies et al., "Expression of M-cadherin, a Member of the Cadherin Multigene Family, Correlates with Differentiation of Skeletal Muscle Cells", PNAS, USA, 88:8024-8028 (Sep. 1991).
Frixen et al., "E-Cadherin-Mediated Cell-Cell Adhesion Prevents Invasiveness of Human Carcinoma Cells", J. Cell Biol., 113(1): 173-185 (Apr. 1991).
Fujimori et al., "Ecotopic Expression of N-cadherin Perturbs Histogenesis in Xenopus Embryos", Development, 110:97-103 (1990).
Gallin et al., "Sequence Analysis of a cDNA Clone Encoding the Liver Cell Adhesion Molecule, L-CAM", PNAS, USA, 84: 2808-2812 (May 1987).
Goodwin et al., "Desmoglein Shows Extensive Homology to the Cadherin Family of Cell Adhesion Molecules", Biochem. Biophys. Res. Commun., 173(3): 1224-1230 (Dec. 31, 1990).
Hatta et al., "Cloning and Expression of cDNA Encoding a Neural Calcium-dependent Cell Adhesion Molecule: Its Identity in the Cadherin Gene Family", J. Cell Biol., 106: 873-881 (Mar. 1988).
Holton et al., "Desmosomal Glycoproteins 2 and 3 (desmocollins) Show N Terminal Similarity to Calcium-Dependent Cell-Cell Adhesion Molecules", J. Cell. Science, 97:239-246 (1990).
Inuzuka et al., "R-Cadherin: A Novel Ca.sup.2+ -Dependent Cell-Cell Adhesion Molecule Expressed in the Retina", Neuron, 7: 69-71 (1991).
Kenneth, "Cell Fusion ", Methods in Enzymol, 58:345-359 (1978).
Kintner et al., "Regulation of Embryonic Cell Adhesion by the Cadherin Cytoplasmic Domain", Cell, 69:225-236 (Apr. 17, 1992).
Koch et al., "Identification of Desmoglein, a Constitutive Desmosomal Glycoprotein, as a member of the Cadherin Family of Cell Adhesion Molecules", Eur. J. Cell Biol, 53: 1-12 (1990).
Liaw et al., "Identification and Cloning of Two Species of Cadherins in Bovine ENdothelial Cells", EMBO J., 9(9): 2701-2708 (1990).
Mahoney et al., "The fat Tumor Suppressor Gene in Drosophila Encodes a Novel Member of the Cadherin Gene Superfamily", Cell, 67: 853-868 (Nov. 29, 1991).
Maniatis et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor, New York: Cold Spring Harbor Laboratory, p. 196 (1982).
Maruyama et al., "Detection of Calcium Binding Proteins by .sup.45 Ca Autoradiography on Nitrocellulose Membrane after Sodium Dodecyl Sulfate Gel Electrophoresis.sup.1 ", J. Biochem., 95: 511-519 (1984).
Matsunaga et al., "Guidance of Optic Nerve Fibers by N-cadherin Adhesion Molecules ", Nature, 334: 62-64 (Jul. 1988).
Miyatani et al., "Neural Cadherin: Role in Selective Cell-Cell Adhesion", Science, 245: 631-635 (Aug. 1989).
Nagafuchi et al., "Transformation of Cell Adhesion Properties by Exogenously Introduced E-cadherin cDNA ", Nature , 329: 341-343 (Sep. 1987).
Napolitano et al., "Molecular Cloning and Characterization of B-Cadherin, a Novel Chick Cadherin", J. Cell Biol., 113(4): 893-905 (May 1991).
Nose et al., "Isolation of Placental Cadherin cDNA: Identification of a Novel Gene Family of Cell-Cell Adhesion Molecules", EMBO J., 6(12):3655-3661 (1987).
Porter et al., "Dystrophin Colocalizes with .beta.-Spectrin in Distinct Subsarcolemmal Domains in Mammalian Skeletal Muscle", J. Cell. Biol., 117(5): 997-1005 (Jun. 1992).
Ranscht et al., "T-Cadherin, a Novel Cadherin Cell Adhesion Mol. in the Nervous System Lacks the Conserved Cytoplasmic Region", Neuron, 7: 391-402 (Sep. 1991).
Ringwald et al., "The Structure of Cell-Adhesion Molecule Uvomorulin. Insights into the Molecular Mechanism of Ca.sup.2+ -Dependent Cell Adhesion", EMBO J., 6(12): 3647-3653 (1987).
Shimoyama et al., "Molecular Cloning of a Human Ca.sup.2+ -Dependent Cell-Cell Adhesion Molecule Homologous to Mouse Placental Cadherin: Its Low Expression in Human Placental Tissues", J. Cell Biol., 109: 1787-1794 (Oct. 1989).
Suzuki et al., "Diversity of the Cadherin Family: Evidence for Eight New Cadherins in Nervous Tissue", Cell Regulation, 2: 261-270 (Apr. 1991).
Suzuki et al., "Evidence for Cadherin Superfamily, " Cell. Struc. Func., 16: 605 (Nov. 23, 1991).
Suzuki et al., "Evidence for Cadherin Superfamily", J. Cell. Biol., 115: 72a (Abstract 416) (Dec. 9, 1991).
Takeichi, "Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator", Science, 251: 1451-1455 (Mar. 1991).
Takeichi, "Cadherins: A Molecular Family Important in Selective Cell-Cell Adhesion", Annu. Rev. Biochem., 59: 237-252 (1990).
Thomas, "Hybridization of Denatured RNA and Small DNA Fragments Transferred to Nitrocellulose", PNAS, USA, 77(9): 5201-5205 (Sep. 1980).
Towbin et al., "Electrophoretic Transfer of Proteins from Polyacrylamide Gels to Nitrocellulose Sheets: Procedure and Some Applications", PNAS, 76: 4350-4354 (Sep. 1979).
Urushihara et al., "Immunological Detection of Cell Surface Components Related with Aggregation of Chinese Hamster and Chick Embryonic Cells", Dev. Biol., 70: 206-216 (1979).
Vanderbark et al., "Experimental Allergic Encephalomyelitis and Cellular Immunity in the Lewis Rat", Cell Immunol., 12: 85-93 (1974).
Vleminckx et al., "Genetic Manipulation of E-Cadherin Expression by Epithelial Tumor Cells Reveals an Invasion Suppressor Role", Cell, 66: 107-119 (Jul. 12, 1991).
Brown Karen E.
Doheny Eye Institute
Walsh Stephen
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