Prothrombin complex concentrates, preparation and application th

Details Prothrombin complex concentrates, preparation and application th Prothrombin complex concentrates, preparation and application th

1983-03-17

1984-08-14

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424101, 424177, C07G 700, C07G 1700, A61K 3516

Patent

active

044656238

ABSTRACT:
Procedure for the preparation of a concentrate of prothrombinogenic compound.
This procedure, in which, starting from a source of prothrombinogenic compound, an adsorption is followed by an elution, is characterized by the fact that a source of prothrombinogenic compound and a source of antithrombin III (or AT III) is placed in contact with an adsorbing agent capable of adsorbing both the prothrombinogenic compound and antithrombin III, and that the foregoing occurs in the presence of heparin, at least during the elution stage, and that elution is carried out with an elution agent capable of eluting the prothrombinogenic compound, the AT III and heparin at the same time.
Application of the product obtained, notably to the treatment of blood coagulation difficulties.

REFERENCES:
patent: 3560475 (1971-02-01), Fekete et al.
patent: 4087415 (1978-05-01), Bick et al.
patent: 4411794 (1983-10-01), Schwinn et al.
Blood, vol. 49, No. 2, Feb. 1977, pp. 159-170, White et al.
Thromb. Diath. Haemorrh., 1972, 27(3), pp. 490-501, Swart et al.
Chem. Abs. 77:124372g, 1972, Swart et al.
Chem. Abs. 77:137016u, 1972, Wickerhauser et al.
Chem. Abs. 86:127141c, 1977, White et al.
Thromb. Res. 1978, 12(4), 571-582, Chandra et al.

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