Chemistry: analytical and immunological testing – Sulfur containing
Reexamination Certificate
2005-03-29
2005-03-29
Ponnaluri, Padmashri (Department: 1639)
Chemistry: analytical and immunological testing
Sulfur containing
C436S086000, C436S103000, C436S149000, C436S172000, C435S007100, C435S007200, C435S018000, C435S026000
Reexamination Certificate
active
06872574
ABSTRACT:
The present invention provides methods for analyzing proteomes, as cells or lysates. The analysis is based on the use of probes that have specificity to the active form of proteins, particularly enzymes and receptors. The probes can be identified in different ways. In accordance with the present invention, a method is provided for generating and screening compound libraries that are used for the identification of lead molecules, and for the parallel identification of their biological targets. By appending specific functionalities and/or groups to one or more binding moieties, the reactive functionalities gain binding affinity and specificity for particular proteins and classes of proteins. Such libraries of candidate compounds, referred to herein as activity-based probes, or ABPs, are used to screen for one or more desired biological activities or target proteins.
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Adam Gregory
Cravatt Benjamin F.
Lovato Martha
Patricelli Matthew P.
Sorensen Erik
Gray Cary Ware & Freidenrich LLP
Ponnaluri Padmashri
The Scripps Research Institute
Tran My-Chau T
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