Proteolytic enzyme from blood-sucking nematodes and its uses as

Details Proteolytic enzyme from blood-sucking nematodes and its uses as Proteolytic enzyme from blood-sucking nematodes and its uses as

1985-01-30

1988-11-29

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435218, 435219, 435226, C12N 948, C12N 966, C12N 950, C12N 964

Patent

active

047881496

ABSTRACT:
This invention relates to proteolytic enzymes with elastolytic properties from blood-sucking nematodes (hereinafter called HP enzymes). These enzymes are useful an anti-coagulants and as a means for dissolving fibrin clots. Because of their importance in the mechanism by which blood-sucking nematodes obtain nutrients from the host, HP enzymes would be an effective vaccine for prevention and treatment of these parasites. For the same reason, substances which inhibit HP enzymes would also be effective antithelminic agents.

REFERENCES:
Oya et al., Biol. Abst., Abstract No. 40125, 1978, "Some Properties of Hemoglobin Protease from Ancylostoma caninum".
McLaren et al., Int. J. Parasit., 1974, vol. 4, pp. 39-46, "The Anterior Glands of Adult Necator americanus (Nematoda: Strongyloidea)--II Cytochemical and Functional Studies".
Matthews, Z Parasitenkd, 1982, vol. 68, pp. 81-86, "Skin Penetration by Necator americanus Larvae".
Hotez et al., J. Exp. Med., vol. 157, May 1983, pp. 1594-1603, "Secretion of an Anticoagulant by Ancylostoma Hookworms".
Hotez et al., J. Biol. Chem., vol. 260(12), Jun. 25, 1985, pp. 7343-7348, "Isolation and Characterization of a Proteolytic Enzyme from the Adult Hookworm Ancylostoma caninum".
Hotez et al., J. Cell Biochem., Supp. 10, (10 P&A), 1986, p. 132, "Isolation, Cloning, and Expression of a Protease from Ancylostoma Hookworms".

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