Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Stablizing an enzyme by forming a mixture – an adduct or a...
Patent
1980-06-05
1984-03-27
Nafe, David M.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Stablizing an enzyme by forming a mixture, an adduct or a...
435221, 435273, 435834, C12N 996, C12N 954, C07G 700, C12R 1085
Patent
active
044395221
ABSTRACT:
A proteolytic enzyme-containing composition is prepared having stabilized proteolytic enzyme activity and the ability to convert scleroproteins to water soluble products without racemization. The composition contains a proteolytic enzyme system from Bacillus cereus and an anionic detergent. The proteolytic enzyme system consists of a proteolytic enzyme oligomer that is retained by an ultrafilter membrane that retains molecules larger than 10,000 molecular weight and is reversibly interconvertible with a proteolytic active subcomponent that passes through the same membrane that retains the oligomer. The anionic detergent is preferably an alkyl sulfate or sulfonate or an alkyl-aryl sulfate or sulfonate.
REFERENCES:
patent: 3775254 (1973-11-01), Buetow
patent: 3860485 (1975-01-01), Schenk et al.
Bjorksten, et al., Study of Low, Molecular Weight Proteolytic Enzymes, Finska Kemists, Medd. vol. 80, No. 4, 1971, pp. (70-87).
Schenk, et al., The Search for Microenzymes, Finska Kemists Medd., vol. 82, No. 2, 1973, pp. (26-46).
Kagan et al., Proteolysis of Elastin-Ligand Complexes, Biochemistry, vol. 11, No. 18, 1972, pp. (3412-3418).
Shapiro et al., Molecular Weight Estimation of Polypeptide Chains by Electrophoresis in SDS-Polyacrylamide Gels, Biochem. and Biophys. Res., Comm., vol. 28, No. 5, 1967, pp. (815-820).
Bjorksten Research Laboratories, Inc.
Nafe David M.
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