Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1984-12-06
1986-09-23
Rosen, Sam
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
424 16, 514 55, 514 59, A61K 3748, A61K 37547
Patent
active
046135022
ABSTRACT:
The invention pertains to a cover of wounds in the form of a powder or a dry powdery fluid and is useful in covering and treating of ulcerous and necrotic wounds. It consists of animal or fungous chitin and chitosan in a powdered form of particle size 0.01 to 0.3 mm or of crosslinked dextran in the form of spheric particles of diameter 0.05 to 0.5 mm and of an immobilized protease. Enzymes are chemically bonded to the structure of the biopolymeric carrier and provide cleaning of the wound by dissolution of undesirable protein material, in particular fibrin, necrotic tissues, components of pus, and the like. In addition the adsorption and regeneration effects of powder act to provide suction of exudate and purulent matter infected with bacteria into interstitial capillary space. The cover according to the invention acts by fast cleaning of necrotic defects and speeds up the granulation and healing of the wound. The invention can be utilized in pharmaceutical production.
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patent: 3003917 (1961-10-01), Beiler et al.
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patent: 4361551 (1982-11-01), Galbraith
Nozawa et al., Chem. Abst., vol. 96 (1982), p. 195855v.
Stamberg Jiri
Turkova Jaroslava
Ceskoslovenska akademie ved
Rosen Sam
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