Proteoliposomes as drug carriers

Details Proteoliposomes as drug carriers Proteoliposomes as drug carriers

1988-03-21

1989-10-10

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

A61K 3722

Patent

active

048730890

ABSTRACT:
A process for the preparation of proteoliposomes comprising: (1) mixing a fusogen with lipid components used to form unilamellar lipid vesicles to thereby form fusogenic unilamellar lipid vesicles; and (2) activating the fusogenic unilamellar lipid vesicles in the presence of integral membrane proteins to thereby form fusogenic proteoliposomes, wherein the fusogenic unilamellar lipid vesicles are activated by lowering the temperature of the mixture of fusogenic unilamellar lipid vesicles and integral membrane proteins to at or below the phase transition temperature of the fusogenic unilamellar lipid vesicles. A proteoliposome, a medicament comprising the proteoliposome and a drug or other biologically or physiologically active agent, and a method of treatment comprising administering the medicament to an afflicted host are also disclosed. The proteoliposomes are larger than conventional proteoliposomes and are more stable than conventional unilamellar lipid vesicles.

REFERENCES:
patent: 3937668 (1976-02-01), Zolle
patent: 4560665 (1985-12-01), Nakae et al.

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