Proteoglycan degrading mutants for the treatment of CNS

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing

Reexamination Certificate

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C424S094500, C435S232000

Reexamination Certificate

active

07429375

ABSTRACT:
The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system (“CNS”) injury or disease.

REFERENCES:
patent: 7008783 (2006-03-01), Sato et al.
patent: 2005/0233419 (2005-10-01), Pojasek et al.
patent: 2006/0078959 (2006-04-01), Prabhakar et al.
patent: 94/25567 (1994-11-01), None
Yamagata, T., et al., J. Biol. Chem. 243:1523, 1968, (Abstract only).
Sato et al., Agric. Biol. Chem. 50(4):1057-1059, 1986.

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