Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-06-07
1998-06-30
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
4241951, 514 8, 514866, 530395, 5361231, 53612312, A61K 31715, A61K 3578, C07K 410
Patent
active
057734267
ABSTRACT:
This Invention is to provide a proteoglucan and an antidiabetes drug containing the proteoglucan, as an active ingredient, which possess an excellent effect against non-insulin dependent diabetes mellitus. The proteoglucan under this Invention has .beta.-1,6 main chain with .alpha.-1,4 branched, with the average molecular weight of 2.times.10.sup.5, acting positive both in anthrone-sulfuric acid method and Lowry's method, having the chemical structure as indicated in the following general formula. ##STR1## The above proteoglucan is obtained easily through the hot-water extraction from fruit body and/or mycellium of Maitake and/or Chorei Maitake. This proteoglucan has an activity to ameliorate the glucose transport and bioavailability at myocardium, skeltal muscles and fat tissue cells, etc. of the patient with non-insulin dependent diabetes mellitus, and is very useful as a pharmaceutical composition to treat and/or prevent from non-insulin dependent diabetes mellitus.
REFERENCES:
Yoshida et al. Nippon Shokuhin Kagaku Kogaku Kaishi, vol. 43 No. 6, pp. 748-755, (1996).
Keiko Kubo et al., "Anti-diabetic Activity Present in the Fruit Body of Grifola frondosa (Maitake).I,"Biol.Pharm.Bull., 17(8): 1106-1110(1994).
Masashi Tomoda et al., "Glycan Structures of Ganoderans B and C, Hypoglycemic Glyacans of Ganoderma Lucidum Fruit Bodies*," Phytochemistry, 25(12): 2817-2820 (1986).
Kight John
Lee Howard C.
Masaki Shirota
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