Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1991-12-03
1999-02-23
Smith, Lynette F.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530350, C07K 100, C07K 1400, C07K 1700, A61K 3800
Patent
active
058745360
ABSTRACT:
The present invention is directed to biologically mutant forms of the cell growth regulatory factor Oncostatin M. The Oncostatin M mutants of the invention comprise deletion, substitution and insertion mutants and may be prepared using recombinant DNA, in vitro mutagenesis and heterologous expression techniques. Oncostatin M mutants may be useful in eliciting Oncostatin M biological responses and, as such, may find a variety of therapeutic uses including but not limited to the treatment of neoplasias.
REFERENCES:
Zarling et al., 1986, Proc. Natl. Acad. Sci. USA 83:9739-9743.
Brown et al., 1987, J. Immunol. 134:2977-2483.
European Patent Application 0290948, published Nov. 17, 1988.
Linsley et al., 1989, J. Biol. Chem. 264:4282-4289.
Malik et al., 1989, Mol. Cell. Biol. 9:2847-2853.
Kallestad Jeffery C.
Linsley Peter S.
Bristol--Myers Squibb Company
Smith Lynette F.
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