Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-01-27
2000-10-31
Jagannathan, Vasu
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4351721, 4352523, 4353201, 530350, 530385, C12P 2106, C12N 120, C12N 1500, C07K 100
Patent
active
061400718
ABSTRACT:
This invention relates to proteins with N-terminal modifications in their amino acid sequence that reduce or eliminate the methylation of the N-terminal methionine that occurs when such proteins are produced in bacteria such as E. coli.
REFERENCES:
patent: 4377512 (1983-03-01), Ajisaka et al.
patent: 4600531 (1986-07-01), Walder
patent: 4696816 (1987-09-01), Brown
patent: 4831012 (1989-05-01), Estep
patent: 4861867 (1989-08-01), Estep
patent: 4873192 (1989-10-01), Kunkel
patent: 5084558 (1992-01-01), Rausch et al.
Brittis et al., "Chondroitin Sulfate as a Regulator of Neuronal Patterning in the Retina" Science, vol. 255, pp. 733-736, (Feb. 7, 1992).
Caterson et al., "Modulation of native chondroitin sulphate structure in tissue development and in disease" Journal of Cell Science, vol. 97, Part 3, pp. 411-417, (Nov. 1990).
Guthrie and Salyers, "Evidence that the Bacteroides thetaiotaomicron Chondroitin Lyase II Gene Is Adjacent to the Chondro-4-Sulfatase Gene and May Be Part of the Same Operon" Journal of Bacteriology, vol. 169, No. 3, pp. 1192-1199, (Mar., 1987).
Henderson et al., "Nucleolysis of the Rabbit Intervertebral Disc Using Chondroitinase ABC" Spine, vol. 16, No. 2, pp. 203-208, (1991).
Kato et al., "Experimental Chemonucleolysis With Chondroitinase ABC" Clinical Orthopaedics and Related Research , vol. 253, pp. 301-308, (Apr., 1990).
Linker et al., "The Formation of Unsaturated Disaccharides from Mucopolysaccharides and Their Cleavage to .alpha.-Keto Acid by Bacterial Enzymes" Journal of Biological Chemistry, vol. 235, No. 11, pp. 3061-3065, (Nov., 1960).
McKeon et al., "Reduction of Neurite Outgrowth in a Model of Glial Scarring following CNS Injury Is Correlated with the Expression of Inhibitory Molecules on Reactive Astrocytes" The Journal of Neuroscience, vol. 11, No. 11, pp. 3398-3411, (1991).
Neuberg and Hofman, "Enzymatischer Abbau von Chondroitinschwefelsaure" Biochemische Zeitschrift, vol. 234, pp. 345-346, (1931). (No translation).
Neuberg and Rubin, "Uber die Bildung von Thioschwefelsaure und Schwefelsaure aus Atherschwefelsauren und Sulfonsauren" Biochemische Zeitschrift, vol. 67, pp. 82-89, (1914). (No translation).
Pettipher et al., "Cartilage Proteoglycan Depletion in Acute and Chronic Antigen-Induced Arthritis" Arthritis and Rheumatism, vol. 32, No. 5, pp. 601-607, (May, 1989).
Reissig et al., "A Modified Colorimetric Method for the Estimation of N-Acetylamino Sugars" The Journal of Biological Chemistry, vol. 217, pp. 959-966, (1955).
Saito et al., "Enzymatic Methods for the Determination of Small Quantities of Isomeric Chondroitin Sulfates" The Journal of Biological Chemistry, vol. 243, No. 7, pp. 1536-1542, (Apr. 10, 1968).
Sato et al., "Cultural Conditions for the Induction of Chondroitinase ABC in Proteus vulgaris Cells" J. Ferment. Technol., vol. 64, No. 2, pp. 155-159, (1986).
Sato et al., "Growth-Promoting Activity of Tuna Growth Hormone and Expression of Tuna Growth Hormone cDNA in Escherichia coli" Biotechnology and Applied Biochemistry, vol. 10, pp. 385-393, (1988).
Sato et al., "Subunit Structure of Chondroitinase ABC from Proteus vulgaris" Agric. Biol. Chem., vol. 50, No. 4, pp. 1057-1059, (1986).
Seibel et al., "Antigen Properties of Keratan Sulfate: Influence of Antigen Structure, Monoclonal Antibodies, and Antibody Valency" Archives of Biochemistry and Biophysics, vol. 296, No. 2, pp. 410-418, (Aug. 1, 1992).
Thurston, "Induction and Catabolite Repression of Chondroitinase in Batch and Chemostat Cultures of Proteus vulagris" Journal of General Microbiology, vol. 80, pp. 515-522, (1974).
Yamagata et al., "Purification and Properties of Bacterial Chondroitinases and Chondrosulfatases" The Journal of Biological Chemistry, vol. 243, No. 7, pp. 1523-1535, (Apr. 10, 1968).
Brown et al., Intradiscal Therapy, Year Book Medical Publishers, inc. Chicago, (1983).
Sato et al., Biotechnol. Bioeng., vol. 28, pp. 1707-1712, (1986).
De Boer, H.A. et al/The Tac Promoter: A Functional Hybrid Derived from the TRP and LAC Promoters/PNAS/(1983), 80: 21-25.
Dente/DNA Cloning/Glover Ed./IRL Press/(1985), 101-107.
Dickerson, R.E. & Geis, I./Hemoglobin, Structure, Function, Growth and Pathology/ Evolution of the Oxygen Carriers/(1983), Chapter 3/66-115/Benjamin Cummings Publishing Co/California.
Didonato, A. et al/Selective Carboxymethylation of the .alpha.-Amino Groups of Hemoglobin Effect on Functional Properties/J. Biological Chemistry/(1983), 258(19): 11890-11895.
Farabaugh, P.J./Sequence of the lacI Gene/Nature/(1978), 274: 765-769.
Fujiyama, A & Tamanoi, F./RAS2 Protein of Saccharomyces Cerevisiae Undergoes Removal of Methionine at N Terminus and Removal of Three Amino Acids at C Terminus/(1990), 265: 3362-3368.
Hirel, H. et al/Extent of N-Terminal Methionine Excision From Escherichia Coli Proteins is Governed by the Side-Chain Length of the Penultimate Amino Acid/PNAS/(1989), 86: 8247-8251.
Jones, D.H. & Howard, B.H./A Rapid Method for Site-Specific Mutagenesis and Directional Subcloning by Using the Polymerase Chain Reaction to Generate Recombinant Circles/Biotechniques/(1990), 8(2): 178-183.
Jones, D.H. & Howard, B.H./A Rapid Method for Recombination and Site-Specific Mutagesesis by Placing Homologous Ends on DNA Using Polymerase Chain Reaction/Biotechniques/ (1991), 10(1), 62-66.
Kunkel, T.A. et al./Rapid and Efficient Site-Specific Mutagenesis Without Phenotypic Selection/Methods in Enzymololgy/(1987), 154: 367-382.
Looker, D. et al/A Human Recombinant Haemoglobin Designed for Use as a Blood Substitute/Nature/(1992), 356: 258-260.
Luisi, B.F. & Nagai, K./Crystallographic Analysis of Mutant Human Haemoglobins Made in Escherichia Coli/Nature/(1986) 320: 555-556.
McCracken, A.A. et al/An Enrichment Selection for Mutants Resulting from Oligo-Nucleotide-Directed Mutagenesis of Double-Stranded DNA/Biotechniques/(1988) 6(4): 332-339.
Morgan, D.G. et al/Proteins Antigenically Related to Methyl-Accepting Chemotaxis Proteins of Escherichia Coli Detected in a Wide Range of Bacterial Species/J. Bacteriology/(1993), 175(1): 133-140.
Nagai, K. et al/Distal Residues in the Oxygen Binding Site of Haemoglobin Studied by Protein Engineering/Nature/(1987) 329: 858-860.
Zoller, M.J. & Smith, M./Oligonucleotide-Directed Mutagenesis of DNA Fragments Cloned into M13 Vectors/Methods in Enzymology/(1983) 100: 468-500.
Nakamaye, K.L. & Eckstein, F./Inhibition of Restriction Endonuclease NCII Cleavage by Phosphorothioate Groups and its Application to Oligonucleotide-Directed Mutagenesis/Nucleic Acids Research/(1986) 14(24): 9679-9698.
Paik, W.K./A Simple Analysis of Methylated Proteins/Methods in Enzymology/(1984) 106: 265-268.
Pasloske, B.L. & Paranchych, W./The Expression of Mutant Pilins in Pseudomonas Aeruginosa: Fifth Position Glutamate Affects Pilin Methylation/Molecular Microbiology/(1988) 2(4): 489-495.
Schulz, G.E. & Shirmer, R.H./Principles of Protein Structure/(1979) Table 1-2/Springer-Verlag.
Stock, A./N-Methylmethionine at the Amino Terminus of a Protein Required for Bacterial Chemotaxis/Advances in Post-Translational Modification of Proteins & Aging/Ed. Zappia/(1987) 387-399.
Stock, A. et al/N-Terminal Methylation of Proteins: Structure, Function and Specificity/ FEBS Letters/(1987) 220(1): 8-14.
Stock, A. et al/A Second Type of Protein Methylation Reaction in Bacterial Chemotaxis/ J. of Biological Chemistry/(1987) 262(17): 8011-8014.
Stock A.M. & Stock, J.B./Purification and Characterization of the Chez Protein of Bacterial Chemotaxis/J. of Bacteriology/(1987) 169(7): 3301-3311.
Strom, M.S. & Lory, S./Amino Acid Substitutions in Pilin of Pseudomonas Aeruginosa Effect on Leader Peptide Cleavage, Amino-Terminal Methylation, and Pilus Asssembly/J. of Biological Chemistry/(1991) 266(3): 1656-1664.
Sutcliffe, J.G./ Complete Nucleotide Sequence of the Escherichia Coli Plasmid PBR322/Cold Spring Harbor Symp. Quant. Biol.(1979) 43: 77-90.
Taylor, J.W. et al/The Rapid Generation of Oligonucleotide-Directed Mutations at High Frequency Using Phosphorothioate-Modified DNA/Nucleic Acids Research/(1985) 13(24): 8765-8785.
Taylor, J.W. et al/The Use of Phosphorothioate-Modifi
Aitken Jacqueline F.
Apostol Izydor Z.
Levine Joseph D.
Lippincott Julie A.
Brown Theresa A.
Jagannathan Vasu
Kim Hyosuk
Novelli Marianne F.
Nowak Henry P.
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