Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-02-29
1998-09-22
Carlson, Karen Cochrane
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
530350, 530385, 514 12, C12P 2106, C07K 1400, C07K 1405
Patent
active
058112642
ABSTRACT:
Mutated protein having a sequence with a non-proline amino acid replacement for a proline at amino acid position 4. The mutated protein is not methylated on its N-terminus when expressed in bacteria. The mutated protein is a mutation of a methylated protein that is at least partially methylated on its N-terminus when expressed in bacteria.
REFERENCES:
Dinltzis (1992) Pediatric Res 32:376-385 (Abstract only) "Rational design of conjugate vaccines".
Stock, A./N-Methylmethionine At The Amino Terminus Of A Protein Required for Bacterial Chemotaxis/Adv. Exp. Med. Biol./1988/231: 387-399.
Storm & Lory/Amino Acid Substitutions In Pilin Of Pseudomonas Aeruginosa/J. Of Biol. Chem/1991/266(3):1656-1664.
Stock & Stock/Purification and Characterization of The Chez Protein of Bacterial Chemotaxis/J. of Bacteriology/1987/169(7):3301-3311.
Stock et al./N-Terminal Methylation Of Proteins: Structure, Function And Specificity/FEBS Letters/1987/220(1):8-14.
Stock et al./A Secont Type Of Proetin Methylation Reaction In Bacterial Chemotaxis/J. Of Biological Chemistry/1987/262(17):8011-8014.
Pasloske & Paranchych/The Expression Of Mutant Pilins In Pseudomonas Aeruginosa: Fifth Position Glutamiate Affects Pilin Methylation/1988/2(4):489-495.
Paik, W.K./A Simple Analysis Of Methylated Proteins/Methods In Enzymology/1984/106:265-268.
Morgan et al./Proteins Antigenically Related To Methyl-Accepting Chemotaxis Proteins Of Escherichia Coli Detected in a Wide Range of Bacterial Species/1993/175(1):133-140.
Looker et al/A Human Recombinant Haemoglobin Designed for use as a Blood Substitute/Nature/1992/356-258-260.
Hirel et al./Extent Of N-Terminal Methionine Excision From Escherichia Coli Proteins Is Governed by the Side-Chain Length of the Penultimate Amino Acid/PNAS, USA/1989/86:8247-8251.
Fujiyama & Tamanoi/RAS2 Protein of Saccharomyces Cerevsiae Undergoes Removal of Methionine at N Terminus and Removal of Three Amino Acids at C Terminus/J. of Biological Chemistry/1990/265-3362-3368.
DiDonato et al/Selective Carboxymethylation of the .alpha.-Amino Groups Of Hemoglobin--Effect on Functional Properties/J. Of Biological Chemistry/1983/258(19):11890-11895.
Brosius & Chen/The Primary Structure Of Protein L16 Located At The Peptidyltransferase Center of Escherichia Coli Ribosomes/FEBS Letters/1976/68(1)105-109.
Brauer & Wittmann-Liebold/The Primary Structure of the Initiation Factor IF-3 From Escherichia Coli/FEBS Letters/1977/79(2):269-275.
Stock & Lukat/Bacterial Chemotaxis And The Molecular Logic Of Intracellular Signal Transduction Networks/Ann. Rev. Biophys. Biophys. Chem./1991/20:109-136.
Aitken Jacqueline F.
Apostol Izydor Z.
Levine Joseph D.
Lippincott Julie A.
Brown Theresa A.
Carlson Karen Cochrane
Novelli Marianne F.
Somatogen, Inc.
LandOfFree
Proteins with mutations to decrease N-terminal methylation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Proteins with mutations to decrease N-terminal methylation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Proteins with mutations to decrease N-terminal methylation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1621124