Proteins with factor VIII activity: process for their preparatio

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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530395, 530830, 514 12, 435 696, C07K 1300, A61K 3702

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active

051718448

ABSTRACT:
Novel polypeptides having Factor VIII activity are provided as well as compositions and methods for their preparation. The polypeptides comprise derivatives and fragments of Factor VIII and have sequences substantially similar to portions of naturally occuring Factor VIII. The polypeptides find use in treatment of Hemophilia A.

REFERENCES:
patent: 4868112 (1989-09-01), Toole
Eaton et al. (1986) Prog. Hemostasis and Thrombosis 8, 47-70.
Eaton et al., Biochemistry, Construction and Characterization of an Active Factor VIII Variant Lacking the Central One-Third of the Molecule, (1986) 25:8343-8347.
Burke et al., The Journal of Biological Chemistry, The Functional Domains of Coagulation Factor VIII:C, (1986) 261:12574-12578.

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