Proteins with changed epitopes and methods for the production th

Details Proteins with changed epitopes and methods for the production th Proteins with changed epitopes and methods for the production th

1994-11-29

1998-06-16

Wax, Robert A.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435 691, 435455, 4352523, 43525231, 435220, 435221, 435222, 536 232, 510300, C12N 1509, C12N 1557, C12N 954

Patent

active

057668981

ABSTRACT:
The invention provides methods for selecting where in the amino acid sequence of a protein to modify in order to obtain protein variants evoking a reduced immunological response, and protein variants subsequently produced. Also compositions containing the variants and their use in especially detergents and in medicine is disclosed.

REFERENCES:
patent: 3903068 (1975-09-01), Ruttenberg
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Westhof et al., Nature, vol. 311, No. 13, 1984.
Friguet et al., Molecular Immunology, vol. 21, No. 7, pp. 673-677, 1984.
deLaCruz et al., "Immunogenicity and Epitope Mapping . . . ", Jour. Biol. Chem., 263:9 pp. 4318-4322 Mar. 25, 1988.
Bolwell et al., "Epitope Mapping . . . ", J. Gen. Virol. 70: pp. 59-68, 1989.
Glover, "Recombination and mutagenesis of DNA . . . ", Gene Cloning pp. 21-45. 1984.

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