Proteins which induce immunological effector cell activation and

Details Proteins which induce immunological effector cell activation and Proteins which induce immunological effector cell activation and

1988-02-09

1991-09-17

Moskowitz, Margaret

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Lymphokines, e.g., interferons, interlukins, etc.

530350, 530395, 424 851, C07K 1300

Patent

active

050496590

ABSTRACT:
The present invention relates to genes and their encoded proteins which induce immunological effector cell activation and chemattraction. The proteins of the invention attract subsets of immunological effector cells and stimulate them to express their specialized effector cell functions. Such proteins, termed Ap-1 proteins, are expressed by lymphoid cells, and bind to effector cells such as macrophages and mast cells. In particular, the Ap-1 proteins induce macrophage phagocytosis, expression of class II major histocompatibility molecules, cytotoxicity, and migration, and induce hematopoietic progenitor cell differentiation. The Ap-1 molecules can be of value in the therapy or diagnosis of inflammatory or immune disorders, or neoplasia.

REFERENCES:
patent: 4792525 (1988-12-01), Ruoslanti
Campbell, A. D. et al., "Haemonectin, a Bone Marrow Adhesion Protein . . . ", Nature, vol. 329, pp. 744-746 (10/22/87).
Oldberg, A. et al., "Cloning of Sequence Analysis of Rat Bone Sialoprotein . . . ", Proc. Natl. Acad. Sci, U.S.A., vol. 83, pp. 8819-8823 (12/83).
Miyazaki, Y. et al., "Nucleotide Sequence of cDNA . . . ", Nucleic Acids Research, vol. 17(8), p. 3290 (03/1989).

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