Proteins useful in the regulation of .kappa.B-containing genes

Details Proteins useful in the regulation of .kappa.B-containing genes Proteins useful in the regulation of .kappa.B-containing genes

1991-08-21

1994-06-28

Schwartz, Richard A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

4351723, 935 34, 935 36, 935 11, C07K 1300, C12N 1500

Patent

active

053248180

ABSTRACT:
Proteins, and corresponding DNA and RNA sequences, useful for the regulation of expression of .kappa.B-containing genes are disclosed. These proteins are useful to either stimulate or inhibit the expression of .kappa.B-containing genes. Proteins stimulating the expression of .kappa.B-containing genes have an amino acid sequence at least 80% identical to the amino acid sequence of from position 1 to position 374 of p100 [SEQ ID NO: 2]. Proteins having an inhibitory effect on the expression of .kappa.B-containing genes have sequences either at least 80% identical to the amino acid sequence of from position 407 to the carboxyl end of p100 [SEQ ID NO: 2] or having an amino acid sequence at least 80% identical to the amino sequence of either from position 1 to 100 sor from position 101 to position 374 of p100 [SEQ ID NO: 2].

REFERENCES:
Franza et al., Nature vol. 330, pp. 391-395 (1987).
Ghash et al., Cell vol. 62, pp. 1019-1029 (1990).
Publication-"Tampering with Transcription", by Gary J. Nabel, News and Views, Nature, vol. 350, Apr. 25, 1991, p. 658.
Aids Research Reviews, vol. 1, Chapter 2, by Gary J. Nabel, Marcel Dekker, Inc., New York, Basel, Hong Kong, pp. 21-34, Chapter 2 entitled "Cellular Regulation of Human Immunodeficiency Virus Gene Expression".
Helene et al., Biochimica et Biophysica Acta., vol. 1049, pp. 99-145 (1990).

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