Proteins, their production and use

Details Proteins, their production and use Proteins, their production and use

2006-02-21

2006-02-21

Achutamurthy, Ponnathabura (Department: 1652)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S069100, C435S252300, C435S320100

Reexamination Certificate

active

07001997

ABSTRACT:
This invention relates to a novel metalloprotease having a proteolytic activity, its partial peptide or a salt either of them, a DNA coding for the protein, a recombinant vector comprising the DNA, a transformant carrying the recombinant vector, a process for producing the protein, a pharmaceutical composition comprising the DNA, an antibody against the protein, a method for screening for a compound which activates or inhibits a proteolytic activity of the protein, a kit for screening for the compound, and a compound which activates or inhibits a proteolytic activity of the protein which is identified by the screening method or the kit. The DNA coding for the protein of the present invention can be used as a therapeutic and prophylactic composition for a variety of diseases including diabetic nephropathy, glomerulonephritis, pulmonary fibrosis, hepatolienal fibrosis, hepatocirrhosis, osteopetrosis and herniated disk. Furthermore, the protein of the present invention is useful as a screening reagent for any compounds which activate or inhibit the function of the protein of the present invention. In addition, the antibody against the protein of the present invention specifically recognizes the protein of the present invention and can be used in the quantitative determination of the protein of the present invention in a test fluid.

REFERENCES:
patent: 6399371 (2002-06-01), Falduto et al.
patent: 6566116 (2003-05-01), Koji et al.
patent: WO 97/19178 (1997-05-01), None
patent: WO 97/40157 (1997-10-01), None
Cossins, J., et al., “Identification of MMP-18, a putative novel human matrix metalloprotease”, Biophysical and Biochemical Research Communications, vol. 228, No. 2, pp. 494-498, 1996.
Pendas, A.M., et al., GenEmbl database Accession No. X92521, “H. sapiens mRNA for MMP-19 protein”, electronic publication date Dec. 18, 1996.

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