Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2005-05-24
2005-05-24
Azpuru, Carlos A. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S424000, C514S777000, C514S780000, C514S782000
Reexamination Certificate
active
06896894
ABSTRACT:
Described are heat stable aqueous solutions or gels comprising a biologically effective amount of a protein and an effective stabilizing amount of a polysaccharide gum as well as heat stable solutions or gels suitable for use in an implantable drug delivery device at body temperature. Also disclosed are lyophilized compositions having biologically activity, where such lyophilized compositions are formed by lyophilizing the stabilized solutions or gels of the invention.
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Arakawa, T. et al., Factors Affecting Short-Term and Long-Term Stabilities of Proteins, Advanced Drug Delivery Reviews, 2001, pp. 307-326, vol. 46.
Alavattam Sreedhara
Brody Richard S.
Azpuru Carlos A.
Battelle (Memorial Institute)
Coburn Patricia A.
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