Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Reexamination Certificate
2005-08-30
2005-08-30
Saunders, David (Department: 1644)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
C424S192100
Reexamination Certificate
active
06936249
ABSTRACT:
The present invention relates to a novel methods and compositions for producing hyper and hypo allergenic compositions. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization of an individual to the protein. Alternatively, T-cell epitopes are mutated to produce increased immunogenic reactions. Moreover, naturally occurring proteins are provided.
REFERENCES:
patent: 4261868 (1981-04-01), Hora et al.
patent: 4404128 (1983-09-01), Anderson
patent: 4533359 (1985-08-01), Kondo et al.
patent: 5147642 (1992-09-01), Lotz et al.
patent: 5182204 (1993-01-01), Estell et al.
patent: 5185258 (1993-02-01), Caldwell et al.
patent: 5204015 (1993-04-01), Caldwell et al.
patent: 5264366 (1993-11-01), Ferrari et al.
patent: RE34606 (1994-05-01), Estell et al.
patent: 5314692 (1994-05-01), Haarasilta et al.
patent: 5500366 (1996-03-01), Russell-Jones et al.
patent: 5612055 (1997-03-01), Bedford et al.
patent: 6060281 (2000-05-01), Grieve et al.
patent: 0 134 267 (1989-08-01), None
patent: 0 251 446 (1994-12-01), None
patent: 0 699 755 (1996-03-01), None
patent: WO 89/06279 (1989-07-01), None
patent: WO 92/10755 (1992-06-01), None
patent: WO 94/10191 (1994-05-01), None
patent: 9505849 (1995-03-01), None
patent: WO 96/16177 (1996-05-01), None
patent: WO 96/17929 (1996-06-01), None
patent: WO 96/40791 (1996-12-01), None
patent: WO 97/30148 (1997-08-01), None
patent: WO 98/52976 (1998-11-01), None
patent: 9906061 (1999-02-01), None
patent: WO 99/53038 (1999-10-01), None
patent: WO 99/61637 (1999-12-01), None
patent: WO 00/34317 (2000-06-01), None
Lipford et al, Immunology, 84, 298-303, 1995.
Graziano et al., “Enhancing the Immunogenicity of a Permissive Binding T Cell Epitope derived from the Simian Immunodeficiency Virus-Encoded Negative Regulatory Factor,”J. of Immun.,V. 149, No. 2, 1991, pp. 556-561.
Lipford et al., “Peptide engineering allows cytotoxic T-cell vaccination against human papilloma virus tumour antigen, E6”, Abstract, Database accession No. PREV199598171988.
Altschul et al., “Basic Local Alignment Search Tool,” J. Mol. Biol., vol. 215, pp. 403-410, 1990.
Giver et al., “Directed evolution of a thermostable esterase,” Proc. Natl. Acad. Sci. USA, vol. 95, pp. 12809-12813, 1998.
Harayama, Shigeaki, “Artificial evolution by DNA shuffling,” TIBTECH., vol. 16, 6, pp., 1998.
Heinkoff et al., “Amino acid substitution matrices from protein blocks,” Proc. Natl. Acad. Sci. USA, vol. 89, pp. 10915-10919, 1992.
Karlin et al., “Applications and statistics for multiple high-scoring segments in molecular sequences,” Proc. Natl. Acad. Sci. USA, vol. 90, No. 12, pp. 5873-5788, 1993.
Kuchner et al, “Directed evolution of enzyme catalysts,” TIBTECH, vol. 15, 9, pages, 1997.
Lin et al., “Functional Expression of Horseradish Peroxidase inE. coliby Directed Evolution,” Biotechnol. Prog., vol. 15, pp. 467-471, 1999.
Mathew C. G., “The Isolation of High Molecular Weight Eurkaryotic DNA,” Methods in Mol. Biol., vol. 2, pp. 31-33, 1984.
* Moeller, G., “Antigenic Requirements for Activation of MHC-Restricted Responses,” Immun. Review, vol. 98, 1987.
Moore et al. “Strategies for the in vitro Evolution of Protein Function: Enzyme Evolution by Random Recombination of Improved Sequences,” J. Mol. Biol., vol. 272, pp. 336-347, 1997.
Needleman et al., “A General Method Applicable to a Search for Similiarities in the Amino Acid Sequence of Two Proteins,” J. Mol. Biol., vol. 48, pp. 443-453, 1970.
Pattern et al., “Applications of DNA shuffling to pharmaceutical and vaccines,” Curr. Opinion Biotech., vol. 8, pp. 724-733, 1997.
Pearson et al., “Improved tools for biological sequence comparison.” Proc. Natl. Acad. Sci. USA, vol. 85, pp. 2444-2448, 1997.
Smith et al., “Comparison of Biosequences,” Adv. Appl. Math., vol. 2, pp. 482-489, 1981.
Stemmer, William P.C., “DNA shuffling by random fragmentation and reassembly: In vitro recombination for molecular evolution,” Proc. Natl. Acad. Sci. USA, vol. 91, pp. 10747-10751, 1994.
Sun, F., “Modeling DNA Shuffling,” J. Comp. Biol., vol. 6, pp. 77-90, 1999.
Zhao, H. et al, “Molecular evolution by staggered extension process (StEP) in vitro recombination,” Nature Biotechnology, vol. 16, pp. 258-261, 1998.
Copy of PCT partial search of PCT/US 01/30062.
Estell David A.
Harding Fiona A.
Genencor International Inc.
Genencor International Inc.
Saunders David
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