Proteins producing an altered immunogenic response and...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Reexamination Certificate

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C435S221000, C435S222000, C435S252300, C435S252310, C435S320100, C424S094640, C424S401000, C510S119000, C510S130000, C536S023200

Reexamination Certificate

active

06929939

ABSTRACT:
The present invention relates to novel protein variants that exhibit reduced allergenicity when compared to the parental proteins. Also included are DNA molecules that encode the novel variants, host cells comprising the DNA and methods of making proteins less allergenic.

REFERENCES:
patent: 3755560 (1973-08-01), Dickert et al.
patent: 3929678 (1975-12-01), Laughlin et al.
patent: 4076663 (1978-02-01), Masuda et al.
patent: 4152416 (1979-05-01), Spitzer et al.
patent: 4261868 (1981-04-01), Hora et al.
patent: 4387089 (1983-06-01), De Polo
patent: 4404128 (1983-09-01), Anderson
patent: 4421769 (1983-12-01), Dixon et al.
patent: 4533359 (1985-08-01), Kondo et al.
patent: 4663157 (1987-05-01), Brock
patent: 4760025 (1988-07-01), Estell et al.
patent: 4914031 (1990-04-01), Zukowski et al.
patent: 4937370 (1990-06-01), Sabatelli
patent: 4990452 (1991-02-01), Bryan et al.
patent: 4999186 (1991-03-01), Sabatelli et al.
patent: 5011681 (1991-04-01), Ciotti et al.
patent: 5073371 (1991-12-01), Turner et al.
patent: 5073372 (1991-12-01), Turner et al.
patent: 5087372 (1992-02-01), Toyomoto et al.
patent: 5116741 (1992-05-01), Bryan et al.
patent: 5185258 (1993-02-01), Caldwell et al.
patent: 5204015 (1993-04-01), Caldwell et al.
patent: 5264366 (1993-11-01), Ferrari et al.
patent: RE34606 (1994-05-01), Estell et al.
patent: 5397705 (1995-03-01), Zukowski et al.
patent: 5441882 (1995-08-01), Estell et al.
patent: 5487884 (1996-01-01), Bissett et al.
patent: 5665587 (1997-09-01), Aaslyng et al.
patent: 5677272 (1997-10-01), Ghosh et al.
patent: 5827508 (1998-10-01), Tanner et al.
patent: 5935556 (1999-08-01), Tanner et al.
patent: 5968485 (1999-10-01), Robinson
patent: 5972316 (1999-10-01), Robinson
patent: 6312936 (2001-11-01), Poulose et al.
patent: 6428799 (2002-08-01), Cen et al.
patent: 6586221 (2003-07-01), Graycar et al.
patent: 6586223 (2003-07-01), Sikorski et al.
patent: 6596525 (2003-07-01), Estell et al.
patent: 0 134 267 (1989-08-01), None
patent: 0 130 756 (1991-02-01), None
patent: 0 251 446 (1994-12-01), None
patent: 0 680 745 (2002-11-01), None
patent: WO 89/06279 (1989-07-01), None
patent: WO 92/10755 (1992-06-01), None
patent: WO 94/10191 (1994-05-01), None
patent: WO 95/23780 (1995-09-01), None
patent: WO 95/34280 (1995-12-01), None
patent: WO 96/03964 (1996-02-01), None
patent: WO 96/16636 (1996-06-01), None
patent: WO 96/17929 (1996-06-01), None
patent: WO 96/40791 (1996-12-01), None
patent: WO 97/30148 (1997-08-01), None
patent: WO 98/22085 (1998-05-01), None
patent: WO 99/49056 (1999-09-01), None
patent: WO 99/53078 (1999-10-01), None
patent: WO 00/06110 (2000-02-01), None
patent: WO 00/24372 (2000-05-01), None
patent: WO 01/057578 (2001-02-01), None
patent: WO 02/040997 (2002-05-01), None
Achstetter, Tilman et al., “New Proteolytic Enzymes in Yeast,” Archives of Biochemistry and Biophysics, 207(2): 445-454, 1981.
Altschul, Stephen F. et al., “Basic Local Alignment Search Tool,” J. Mol. Biol., 215: 403-410, 1990.
Ausubel et al. (eds.)Current Protocols,a joint venture between Greene Publishing Assoc. Inc. and John Wiley & Sons Inc. (1997 supplement).
Benton, W. David et al., “Screening λgt Recombinant Clones by Hybridization to Single Plaques in situ,” Science, 196: 180-182, 1977.
CTFAInternational Cosmetic Ingredient Dictionary and Handbook,6thed., pp. 1026-1028 & 1103, 1995.
Giver, Lori et al., “Directed evolution of a thermostable esterase,” Proc. Natl. Acad. Sci. USA, 95: 12809-12813, 1998.
DelMar, E.G. et al., “A Sensitive New Substrate For Chymotrypsin,” Analytical Biochemistry, 99: 316-320, 1979.
Federal Register, 43, No. 166, pp. 38206-38269. Aug. 25, 1978.
Grunstein, Michael et al., “Colony hybridization: A method for the isolation of cloned DNAs that contain a specific gene,” Proc. Natl. Acad. Sci. USA, 72(10): 3961-3965, 1975.
Grusby, Michael J. et al., Mice lacking major histocompatibility complex class I and class II molecules, Proc Nat Acad. USA, 90 :3913-3917, 1993.
Harayama, Shigeaki, “Artificial evolution by DNA shuffling,” Trends Biotechnol., 16 :76-81, 1998.
Henikoff, Steven et al., “Amino acid substitution matrices from protein blocks,” Proc. Natl. Acad. Sci. USA, 89: 10915-10919, 1992.
Herman, Ann E. et al., “Determination of Glutamic Acid Decarboxylase 65 Peptides Presented by the Type I Diabetes-Associated HLA-DQ8 Class II Molecule Identifies an Immunogenic Peptide Motif,” J. Immunol., 163 :6275-6282, 1999.
Karlin, Samuel et al., “Applications and statistics for multiple high-scoring segments in molecular sequences,” Proc. Natl. Acad. Sci. USA, 90: 5873-5877, 1993.
Kuchner, Olga et al., “Directed evolution of enzyme catalysts,” Trends Biotechnol., 15 :523-530, 1997.
Lin, Zhanglin et al., “Functional Expression of Horseradish Peroxidase inE. coliby Directed Evolution,” Biotechnol. Prog., 15 :467-471, 1999.
McCutcheon'sDetergents and Emulsifiers,N. American Edition, 1986.
Moore, Jeffrey C. et al., “Strategies for the in vitro Evolution of Protein Function: Enzyme Evolution by Random Recombination of Improved Sequences,” J. Mol. Biol., 272: 336-347, 1997.
Needleman, Saul B. et al., “A General Method Applicable to the Search for Similarities in the Amino Acid Sequence of Two Proteins,” J. Mol Biol., 48 :443-453, 1970.
Noll, Walter,Chemistry and Technology Silicones,New York Academic Press, 1968.
Patentin User Manual (GenBank, Mountain View CA), p. 101, 1990.
Patten, Philip A. et al., “Applications of DNA shuffling to pharmaceuticals and vaccines,” Current Opinion in Biotechnol., 8:724-733, 1997.
PCR Primer, a Laboratory Manual,Cold Spring Harbor Press, Plainview, NY, 1995.
Pearson, William R. et al., “Improved tools for biological sequence comparison,” Proc. Natl. Acad. Sci. USA, 85:2444-2448, 1988.
Research Disclosure 21634, Apr., 1982.
Sagarin, E.,Cosmetics, Science&Technology,2nded., vol. 1, pp. 189 et seq., 1972.
Sagarin, E.,Cosmetics, Science&Technology,2nded., vol. 1, pp. 32-43, 1972.
Sambrook et al.,Molecular Cloning—A Laboratory Manual.2nded., vol. 1-3, Cold Springs Harbor Publishing, 1989.
Sayre, Robert M., “Physical Sunscreens,” J. Soc. Cosmet. Chem., 41(2):103-109, 1990.
Smith, Temple F. et al., “Comparison of Biosequences,” Adv. Appl. Math. 2:482-489, 1981.
Sønderstrup, Grete et al., “HLA class II transgenic mice: models of the human CD4+T-cell Immune response,” Immunol. Rev., 172:335-343, 1999.
Stemmer, Willem P.C., “DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution,” Proc. Natl. Acad. Sci., USA 91:10747-10751, 1994.
Stickler, M.M. et al., “CD4+T-cell Epitope Determination Using Unexposed Human Donor Peripheral Blood Mononuclear Cells,” J. of Immunotherapy, 23(6):654-660, 2000.
Sun, Fengzhu, “Modeling DNA Shuffling,” J. of Computational Biol., 6(1):77-90, 1999.
Taneja, Veena et al., “HLA class II transgenic mice as models of human diseases,” Immunol. Rev., 169:67-79, 1999.
Taurog, Joel D. et al., “Inflammatory disease in HLA-B27 transgenic rats,” Immunol. Rev., 169:209-223, 1999.
Wenninger, John A. et al., ed. CTFAInternational Cosmetic Ingredient Dictionary and Handbook,7thed., vol., 2, p 1672, 1997.
Zhao, Huimin et al., “Molecular evolution by staggered extension process (StEP) in vitro recombination,” Nature Biotechnology, 16:258-261, 1998.

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