Proteins modified with positively charged carriers and compositi

Details Proteins modified with positively charged carriers and compositi Proteins modified with positively charged carriers and compositi

1989-09-19

1992-11-10

Nucker, Christine M.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530331, 5303913, 530408, 530409, 424 8591, 424 11, 514 21, 525 541, C07K 1706, C07K 1528, A61K 4902

Patent

active

051625059

ABSTRACT:
Protein conjugates comprising a protein covalently linked to at least one positively charged agent, so that the protein conjugate has an overall net positive charge in aqueous conditions at physiological pH are disclosed. The positively charged agents comprise polymers of three or more subunits selected from the group consisting of amino acids containing positively charged side chains and alkylamines. These protein conjugates have decreased blood clearance rates compared to conjugates which do not have the positively charged agents. The protein conjugates may further comprise diagnostic or therapeutic radionuclides bound to the protein or the positively charged agent through bifunctional coupling agents.

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