Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1988-08-19
1992-01-07
Moezie, F. T.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
530350, 530324, 530402, C07K 1300, C07K 710
Patent
active
050793454
ABSTRACT:
This specification describes modified growth hormone having substantially diminished insulin-like and diabetogenic potencies relative to the native hormone with retention of substantially all of the anabolic potency of the native hormone. The modified growth hormone has the following structure: (a) elimination of from 1-5 to 1-19 amino acid residues from the amino terminus of the hormone; (b) cleavage of a peptide bond at any point from the carboxy moiety of residue 127 to residue 153; and (c) optionally, elimination of one or more of amino acid residues 128-152 of the hormone.
REFERENCES:
Lewis et al., Rec. Progr. Horm. Res. 36, 477-508 (1980).
Li et al., Mol. Pharmacol 1, 47-52 (1965).
Graf et al., J. Biol. Chem. 257, 2365-2369 (1982).
Mills et al., Endocrinology 102, 1366-1376 (1978).
Reagan et al., Endocrinology 102, 1377-1386 (1978).
Reagan, C. R. et al., Diabetes 27, 883-888 (1978).
Mills et al., Endocrinology 107, 391-399 (1980).
Reagan et al., Endocrinology 109, 1663-1671 (1981).
Li et al., J. Biol. Chem. 218, 41-52 (1956).
Lewis et al., Biochim. Biophys. Res. Comm. 67, 617-624 (1975).
Mills et al., Biochim. Biophys. Acta 742, 169-174 (1983).
Li, C. H., J. Gen. Physiol. 45, 169-178 (1962).
Lewis et al., Endocrinology 101, 1587-1603 (1977).
Gertler et al., Endocrinology 118, 720-726 (1986).
Ashkenazi et al., Endocrinology 121, 414-419 (1987).
Graf et al., Biochem 13, 5408-5415 (1974).
Maciag et al., J. Biol. Chem. 255, 6064-6070 (1980).
Becker Gerald W.
Shaar Carl J.
Eli Lilly and Company
Jones Joseph A.
Martens William C.
Moezie F. T.
Whitaker Leroy
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