Proteins having fibrinolytic and coagulation--inhibiting propert

Details Proteins having fibrinolytic and coagulation--inhibiting propert Proteins having fibrinolytic and coagulation--inhibiting propert

1995-11-17

1999-11-02

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435226, 4352523, 43525233, 4353201, 435471, 424 9464, 536 232, 536 234, 935 14, 935 29, 935 47, 935 73, C12N 972, C12N 1558, C12N 1562, A61K 3700

Patent

active

059768410

ABSTRACT:
Proteins having fibrinolytic and coagulation-inhibiting properties which are linked at the N- and/or C-terminal end of the plasminogen-activating amino acid sequence to a thrombin- or factor Xa-inhibiting amino acid sequence. The proteins, which are produced by genetic engineering, are useful as thrombolytic agents.

REFERENCES:
patent: 4751180 (1988-06-01), Cousens et al.
patent: 4944943 (1990-07-01), Eschenfelder et al.
patent: 5002887 (1991-03-01), Larsen
patent: 5126134 (1992-06-01), Heim et al.
patent: 5182113 (1993-01-01), Rigbi et al.
patent: 5187098 (1993-02-01), Malke et al.
patent: 5188829 (1993-02-01), Kobayashi et al.
patent: 5189019 (1993-02-01), Palladino et al.
patent: 5194589 (1993-03-01), Bott
patent: 5204255 (1993-04-01), Tagawa et al.
patent: 5242810 (1993-09-01), Maraganore et al.
patent: 5242919 (1993-09-01), Rajput et al.
patent: 5256770 (1993-10-01), Glaser et al.
patent: 5268296 (1993-12-01), Maschler et al.
patent: 5328898 (1994-07-01), Greenberg
patent: 5376367 (1994-12-01), Williams
patent: 5434073 (1995-07-01), Dawson et al.
patent: 5571708 (1996-11-01), Yang et al.
patent: 5637503 (1997-06-01), Brigelius-Flohe et al.
patent: 5648250 (1997-07-01), Niwa et al.
patent: 5681721 (1997-10-01), Steffens et al.
patent: 5747291 (1998-05-01), Steffens et al.
patent: 5801017 (1998-09-01), Werber et al.
Sako, T., et al., Molecular and General Genetics, vol. 190, "Cloning and expression of the staphylokinase gene of Staphylococcus aureus in Escherichia coli", pp. 271-277, 1983.
Harvey, P. P., et al., Proceedings of the National Academy of Sciences, U.S.A., vol. 83, "Cloning and expression of a cDNA coding for the anticoagulant hirudin from the bloodsucking leech, Hirudo medicinalis", pp. 1084-1088, 1986.
Maraganore, J. M., et al., The Journal of Biological Chemistry, vol. 264, "Anticoagulant activity of synthetic hirudin peptides", pp. 8692-8698, 1989.
Han, J. H., et al., Gene, vol. 75, "Cloning and expression of cDNA encoding antistasin, a leech-derived protein having anti-coagulant and anti-metastatic properties", pp. 47-57, 1989.
Gardell, S. J., et al., The Journal of Biological Chemistry, vol. 264, "Isolation, characterization, and cDNA cloning of a vampire bat salivary plasminogen activator", pp. 17947-17952, 1989.
Krstenansky, J. L., et al., FEBS Letters, vol. 269, "The C-terminal binding domain of hirullin P18. Antithrombin activity and comparison to other hirudin peptides", pp. 425-429, 1990.
Neeper, M. P., et al., The Journal of Biological Chemistry, vol. 265, "Characterization of recombinant tick anti-coagulant peptide. A highly-selective inhibitor of blood coagulation factor Xa", pp. 17746-17752, 1990.
Vu, T.-K. H., et al., Cell, vol. 64, "Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation", pp. 1057-1068, 1991.
Gardell, S. J., et al., Circulation, vol. 84, "Effective thrombolysis without marked plasminemia after bolus intravenous administration of vampire bat salivary plasminogen activator in rabbits", pp. 244-253, 1991.
Vu, T.-H. K., et al., Nature, vol. 353, "Domains specifying thrombin-receptor interaction", pp. 674-677, 1991.
Brigelius-Flohe, R., et al., Applied Microbiology and Biotechnology, vol. 36, "High expression vectors for the production of recombinant single-chain urinary plasminogen activator", pp. 640-649, 1992.
Yue, S.-Y., et al., Protein Engineering, vol. 5, "Characterization of the interactions of a bifunctional inhibitor with alpha-thrombin by molecular modeling and peptide synthesis", pp. 77-85, 1992.
Strube, K.-H., et al., The Journal of Biological Chemistry, vol. 268, "Isolation, sequence analysis, and cloning of haemadin", pp. 8590-8595, 1993.
Vlasuk, G. P., Thrombosis and Haemostasis, vol. 70, "Structural and functional characterization of tick anticoagulant peptide (TAP): A potent and selective inhibitor of blood coagulation factor Xa", pp. 212-216, 1993.
T.C. Wun et al., Journal of Biological Chemistry, vol. 257, "Isolation and characterization of urokinase from human plasma" pp. 3276-3283 1982.
H. Heyneker et al., Genetics of Industrial Microorganisms, "Functional expression of the human urokinase gene in E. coli", pp. 214-221 1982.
H. Lijnen et al., Journal of Biological Chemistry, vol. 261, "Activation of plasminogen by pro-urokinase", pp. 1253-1258 1986.
J. Maraganore et al., Biochemistry, vol. 29, "Design and characterization of hirulogs" pp. 7095-7101 1990.
D. Stump et al., Journal of Biological Chemistry, vol. 261, "Urokinase-related proteins in human urine", pp. 1267-1269 1986.
J. Krstenansky et al., Journal of Medicinal Chemistry, vol. 30, "Anticoagulant peptides", pp. 1688-1691 1987.
T. Rydel et al., Science, "The structure of a complex of recombinant hirudin and human alpha-thrombin", pp. 227-280 1990.
J. Robinson et al., Tibtech, vol. 9, "Redesigning t-PA for improved thrombolytic therapy", pp. 86-90 1991.
J. Schneider, Thrombosis Research, vol. 64, "Heparin and the thrombin inhibitor", pp. 677-687 1991.
H. Lu et al., Blood, vol. 78, Comparative thrombolytic properties of bolus injectins and continuous infusions of a chimeric anticoagulant, pp. 125-131 1991.
D. Collen et al., Blood, vol. 78, "Basic and clinical aspects of fibrinolysis and thrombolysis", pp. 3114-3124 1991.
H.R. Lijnen et al., Thrombosis and Haemostasis, vol. 66, "Strategies for the improvement of thrombolytic agents", pp. 88-110 1991.
N. Fromage et al., Fibrinolysis, vol. 5, "Synthesis purification and biological properties of a truncated mutant form of human tissue plasminogen activator produced in E. coli", pp. 187-190 1991.
A. Gruber et al., Circulation, vol. 84, "Antithrombotic effects of combining activated protein C and urokinase in nonhuman primates", pp. 2454-2462 1991.
S.K. Yao et al., Journal of the American Physiological Society, "Thrombin inhibition enhances tissue-type plasminogen", pp. 374-379 1992.
A. Szczeklik et al., Arteriosclerosis nd Thrombosis, vol. 12, "Persistent generation of thrombin after acute myocardial infarction", pp. 548-553 1992.
M. Mellott et al., Arteriosclerosis and Thrombosis, vol. 12, "Vampire bat salivary plasminogen activator", pp. 212-221 1992.
Gardell et al., "Isolation, Characterization, and cDNA Cloning of a Vampire Bat Salivary Plasminogen Activator", The Journal of Biological Chemistry, vol. 264, No. 30, Oct. 25, 1989, pp. 17947-17952.
Collen et al., "Thrombolytic and Pharmacokinetic Properties of Human Tissue-Type Plasminogen Activator Variants, Obtained by Deletion and/or Duplication of Structural/Functional Domains, in a Hamster Pulmonary Embolism Model", Thrombosis and Haemostasis, F.K. Schauttauer Verlagsgesellschaft mbH, Stuttgart, 65 (2) pp. 174-180, 1991.
Steffens et al., "The Complete Amino Acid Sequence of Low Molecular Mass Urokinase from Human Urine", Hoppe-Seyler's Z. Physical Chemistry, BD. 363, S. 1043-1058, Sep. 1982.
Guenzler et al., "The Primary Structure of High Molecular Mass Urokinase from Human Urine: The Complete Amino Acid Sequence of the A Chain", Hoppe-Seyler's Z. Physical Chemistry, BD. 363, S. 1155-1165, Sep. 1982.

Affiliated with

Also associated with

Rating

Proteins having fibrinolytic and coagulation--inhibiting propert does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Proteins having fibrinolytic and coagulation--inhibiting propert, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Proteins having fibrinolytic and coagulation--inhibiting propert will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2133470