Proteins having anticoagulant properties

Details Proteins having anticoagulant properties Proteins having anticoagulant properties

1992-04-29

1993-08-24

Hill, Jr., Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Lignins or derivatives

Aldehyde, ketone or ozone reacted with a lignin or lignin...

530334, 530354, 530384, C07K 1300, A61K 3702

Patent

active

052390586

ABSTRACT:
Proteins which specifically inhibit coagulation Factor Xa. The inhibitors, which do not inhibit Factor VIIa, kallikrein, trypsin, chymotrypsin, thrombin, urokinase, tissue plasminogen activator, plasmin, elastase, Factor XIa or S. aureus V8 protease, are polypeptides of 60 amino acid residues. The inhibitors may be purified from Ornithodoros moubata extract, synthesized, or produced using a recombinant DNA yeast expression system.

REFERENCES:
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Stewart & Young "Chemistry of SPPS" Solid Phase Peptide Synthesis, Pierce Chem. Co. (1984).
Vermulen, et al. Int. J. Biochem, vol. 20, No. 6, pp. 621-631 (1988).
Willadsen & Riding, Biochem. J., vol. 189, pp. 295-303 (1980).
Markwardt et al., Naturwissenschaften, vol. 45, pp. 398-399 (1958).
Markwardt et al., Naturwissenschaften, vol. 48 p. 433 (1961).
Hellmann & Hawkins, Thrombosis et Diathesis Haemorrhagica, vol. 18(3) pp. 617-62 (1967).
Ribeiro, J., J. Exp. Med. vol. 161, pp. 332-344 (1985).

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