Proteins having a reverse transcriptase motif

Details Proteins having a reverse transcriptase motif Proteins having a reverse transcriptase motif

2005-09-27

2005-09-27

Myers, Carla J. (Department: 1634)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C530S350000, C536S023200, C536S023500

Reexamination Certificate

active

06949373

ABSTRACT:
The present invention aims to provide a novel gene having a reverse transcriptase motif. The invention isolates a novel gene having a reverse transcriptase motif, and gives its complete base sequence determined. The invention also provides a protein encoded by the gene, and an antibody against the protein. The use of them is useful in developing a method for detecting telomerase activity, a method for detecting a cancer cell, a telomerase activity inhibitor, and a method for screening a telomerase activity inhibitor.

REFERENCES:
patent: WO 98/37181 (1998-08-01), None
patent: WO 99/01560 (1999-01-01), None
M. Meyerson et al., “hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization”, Aug. 22, 1997,Cell, vol. 90, p. 785-795.
Toru Nakamura et al., “Telomerase Catalytic Subunit Homologs from Fission Yeast and Human”, Aug. 15, 1997,Science, vol. 277, p. 955-959.
Meyerson, et al. HEST2, The Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and During Immortalizatgion (1997),Cell(90):785-795.
Nakamura, et al. Telomerase Catalytic Subunit Homologs from Fission Yeast and Human (1997)Science(277): 955-959.

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