Proteins capable of regulating NF-.kappa.B, JNK and apoptosis pa

Details Proteins capable of regulating NF-.kappa.B, JNK and apoptosis pa Proteins capable of regulating NF-.kappa.B, JNK and apoptosis pa

1999-08-24

2000-12-12

Johnson, Nancy A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 14435, C07K 1447

Patent

active

061600954

ABSTRACT:
Testing methods are provided for determining whether given candidate compounds are effective for regulating NF-.kappa.B, JNK and apoptosis cell activities. The methods involve forming a mixture including a compound such as a proteinaceous specie containing two death effector domains (DEDs) or structural or functional homologs and analogs thereof, the candidate compound and a binding target capable of specifically binding to at least one of the DEDs. This mixture is incubated under conditions such that, but for the presence of the candidate compound, the cell activity takes place to a determinable extent. After incubation, the activity is determined and is compared with the determinable extent thereof in the absence of the candidate compound. The assays may be carried out intracellularly or in a cell-free assay. Methods for altering NF-.kappa.B, JNK and apoptosis activities in the cell are also provided, and comprise introducing into the cell an activity-regulating amount of a dual DEDs-containing proteinaceous specie.

REFERENCES:
patent: 5837837 (1998-11-01), Hunter et al.
Boldin et al, Involvement of MACH, a Novel MORT-FADD-Interacting Protease, in Fas/APO-1 and TNF Receptor-Induced Cell Death, Cell, vol. 85, pp. 803-815.

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