Proteins

Details Proteins Proteins

2009-08-26

2011-12-27

Goddard, Laura B (Department: 1642)

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

C424S181100

Reexamination Certificate

active

08084034

ABSTRACT:
The present invention provides new polypeptides. Said polypeptides are of use in the screening, diagnosis and prognosis of B-cell non-Hodgkin's lymphoma, breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer, lymphoid leukaemia (particularly acute T-cell leukaemia), melanoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer and renal cell cancer, in monitoring the effectiveness of B-cell non-Hodgkin's lymphoma, breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer, lymphoid leukaemia (particularly acute T-cell leukaemia), melanoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer and renal cell cancer treatment, and in drug development. Also provided are antibodies (and other affinity reagents such as Affibodies) which interact with or modulate the expression or activity of the polypeptides.

REFERENCES:
patent: 2005/0123982 (2005-06-01), Zhu et al.
patent: 2005/0255114 (2005-11-01), Labat et al.
patent: 03042661 (2003-05-01), None
patent: 2004009622 (2004-01-01), None
Stancovski et al (PNAS, 1991, 88:8691-8695).
Afar, D et al, “Cancer/angiogenesis/fibrosis-related polypeptide, SEQ ID No. C301” XP002480379 retrieved from EBI—Database Accession No. ADN39931.
Afar, D et al, “Cancer/angiogenesis/fibrosis-related nucleic acid, SEQ ID No. C86” XP002480380 retrieved from EBI—Database Accession No. ADN39714.
Labat, I., et al, “Human placental protein, SEQ ID No. 1168” XP002480382 retrieved from EBI—Database Accession No. AED74340.
Labat, I., et al, “Human placental protein encoding cDNA SEQ ID No. 316” XP002480383 retrieved from EBI—Database Accession No. AED73488.
Labat, I., et al, “Large neutral amino acid transporter small unit for anti-cancer complex,” XP002480381 retrieved from EBI—Database Accession No. ADJ66651.

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