Proteinase K resistant surface protein of Neisseria...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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Reexamination Certificate

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07833717

ABSTRACT:
The identification of a highly conserved, immunologically accessible antigen at the surface ofNeisseriafacilitates treatment, prophylaxis, and diagnosis ofNeisseriadiseases. This antigen is highly resistant to Proteinase K and has an apparent molecular weight of 22 kDa on SDS-PAGE. Specific polynucleotides encoding proteins of this class have been isolated from threeNeisseria meningitidisstrains and from oneNeisseria gonorrhoeaestrain. These polynucleotides have been sequenced, and the corresponding full-length amino acid sequences of the encoded polypeptides have been deduced. Recombinant DNA methods for the production of theNeisseriasurface protein, and antibodies that bind to this protein are also disclosed.

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