Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1988-02-02
1989-05-02
Thexton, Matthew A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514773, 514938, 514801, 252356, 426586, A01N 6102
Patent
active
048268186
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
This invention relates to a proteinaceous emulsifier that causes little irritation to the skin or the like, exhibits strong emulsifying power and possesses moisture retention properties, a process for preparing the same, as well as emulsion type cosmetic compositions. such as creams and the like, containing the same.
BACKGROUND ART
Generally, emulsifiers are widely used in cosmetics, foods and the like. Emulsifiers used in cosmetics include anionic surfactants and nonionic surfactants. However, these emulsifiers are disadvantageous in that anionic surfactants are irritable to the skin and in that nonionic surfactants fail to exhibit sufficient emulsifying power and are more or less irritable to the skin. Moreover, since these emulsifiers cannot impart water retention properties to creams and the like, a moisture retentive agent such as glycerol or the like is added thereto according to the existing state of the art. However, this causes problems because the emulsion stability and/or feeling of the cosmetic may be altered.
Emulsifiers used in foods include sugar esters, fatty acid monoglycerides and the like. These emulsifiers and disadvantageous in that, since their emulsifying power is not so strong, they must be used in large amounts to achieve a sufficient degree of emulsification. Accordingly, it is desired to provide an emulsifier that causes little irritation to the skin, exhibits strong emulsifying power and possesses moisture retention properties.
DISCLOSURE OF THE INVENTION
In view of the above-described state of the art, an object of the present invention is to provide an emulsifier which causes little irritation to the skin, exhibits strong emulsifying power and possesses moisture retention properties, a process for preparing such an emulsifier, and emulsion type cosmetic compositions containing such an emulsifier.
According to one feature of the present invention, there is provided a proteinaceous emulsifier composed of decomposition product of a hydrophilic protein having a carboxyl end group joined to the amino group of an amino acid ester by amide linkage.
According to another feature of the present invention, there is provided a process for preparing proteinacous emulsifiers which comprises providing an amino acid ester and a hydrophilic protein and reacting the amino acid ester with the hydrophilic protein in the presence of an endopeptidase to form a proteinaceous emulsifier composed of decomposition products of the hydrophilic protein having a carboxyl end group joined to the amino group of the amino acid ester.
According to still another feature of the present invention, there is provided a process for preparing proteinaceous emulsifiers in which, where the aforesaid amino acid ester is represented by the general formula (I) given below, the amino acid ester is reacted with the hydrophilic protein to form a decomposition product of the hydrophilic protein having a carboxyl end group joined to the amino group of the amino acid ester, and the resulting reaction product is subjected to dialysis.
According to a further feature of the present invention, there is provided an emulsion type cosmetic composition containing, as the emulsifier, a proteinaceous emulsifier composed of a decomposition product of a hydrophilic protein having a carboxyl end group joined to the amino group of an amino acid ester by amide linkage.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is a schematic view illustrating a molecule of the proteinaceous emulsifier of the present invention;
FIGS. 2 and 3 are infrared absorption spectra of amino acid ester p-toluenesulfonates used in the preparation of emulsifiers in accordance with the present invention;
FIGS. 4 and 5 are infrared absorption spectra of free amino acid esters used in the preparation of emulsifiers in accordance with the present invention;
FIGS. 6 and 8 are infrared absorption spectra of proteinaceous emulsifiers in accordance with the present invention;
FIGS. 9 to 11 are surface tension diagrams of proteinaceous emulsifiers in accor
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Arai Sohichi
Matsui Masashi
Mori Kenji
Morita Kazuyoshi
Nagasawa Hisanao
Kanebo Ltd.
Kilby Catherine S.
Thexton Matthew A.
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