Proteinaceous compositions having an activity on erythropoiesis

Details Proteinaceous compositions having an activity on erythropoiesis Proteinaceous compositions having an activity on erythropoiesis

1992-12-09

1996-01-09

Walsh, Stephen G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 514814, 530350, 530395, 530415, 530416, 530417, 530420, A61K 3816, C07K 116, C07K 130, C07K 1447

Patent

active

054829240

ABSTRACT:
The invention relates to proteinaceous compositions capable of modulating the development of erythroid progenitors such as obtainable from a biological material selected from bone marrow culture supernatants, or kidney cell lysates by contacting said biological material with a specific ligand for the proteinaceous compositions, desorbing said proteinaceous compositions and recovering same by elution. Said compositions are useful in therapeutics.

REFERENCES:
patent: 4894440 (1990-01-01), Rosenberg
patent: 4987121 (1991-01-01), Baertschi et al.
patent: 5032507 (1991-07-01), Yu et al.
Kohama et al "A Burst-Promoting Activity Derived from the Huamn Bone Marrow Stromal Cell Line K.mu.-102 . . . " Exp. Haematol. 16:603-608 (1988).
Royet et al, Blood 76(10): 1965-1971, Nov. 15, 1990.
Oddos et al, J. Cell. Physiol. 133:72-78, 1987.
Porter et al, Blood 59(6): 1207-1212, Jun. 1982.
Clark et al, Science 236: 1229-1237, Jun. 5, 1987.
Kohama et al, Exp. Hematol 16(7): 603-608, 1988, abstracted in Biol. Abstr. 86(8): AB-527, Ref. No. 80836, Oct. 1988.
Eliason et al, Cell Tissue Kinet. 16(1): 65-76, 1983, abstracted in Biol. Abstr. 76(1): 75, Ref No 673, 1983.

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