Proteinaceous antigens with conformation-independent and conform

Details Proteinaceous antigens with conformation-independent and conform Proteinaceous antigens with conformation-independent and conform

1985-03-06

1987-07-28

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Lymphokine

435 5, 435184, 435948, 435 7, 436 86, 436543, 436820, 436518, 530402, 530403, 530826, A61K 3912

Patent

active

046831363

ABSTRACT:
A single polypeptide antigen that includes the amino acid residue sequence and epitope of a conformation-independent antigenic determinant and the amino acid residue sequence but lacks the epitope of a conformation-dependent antigenic determinant is disclosed as are methods of its manufacture and use and articles of manufacture using the same. The uses of the pre-S(2) region polypeptide encoded by the hepatitis B virus genome as a T cell proliferating agent and as a potentiator for enhancing the humoral immune response of animals that exhibit a low humoral response to an S region-containing immunogen are also disclosed.

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Bittle et al, Nature, 298 30 (1982).
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