Protein with vascular activity derived from monocytes and its an

Details Protein with vascular activity derived from monocytes and its an Protein with vascular activity derived from monocytes and its an

1988-08-10

1991-12-10

Nutter, Nathan M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

6 to 7 amino acid residues in defined sequence

530327, 530350, 530395, C07K 300, A61K 3702

Patent

active

050719564

ABSTRACT:
This invention has as its object a protein, preferably a glycosylated protein, having a molecular weight of about 0.6 to 200 kD, containing the following sequence which is in particular N-terminal:

REFERENCES:
Henson et al, "Tissue Injury in Inflammation" J. Clin. Invest., vol. 79, Mar. 1987, 669-674.
Heimark et al, "Inhibition of Endothelial Regeneration by Type-Beta Transforming Growth Factor from Platelets" Science, vol. 233, Sep 5, 1986, 1078-1080.
Glenn et al, "Human Monocyte-Derived Growth Factor(s) for Mesenchymal Cells" Cell, vol. 25, 603-615, Sep. 1981.
Martinet et al, "Activated Human Monocytes Express the C-SIS Proto-Oncogene and Release a Mediator Showing PD6F-like Activity" Nature, vol. 319, Jan. 9, 1986, 158-160.

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