Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2003-12-04
2008-11-18
Ramirez, Delia M. (Department: 1656)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023500, C435S320100, C435S252300, C435S041000, C435S325000, C435S410000, C530S350000
Reexamination Certificate
active
07452983
ABSTRACT:
A novel polypeptide, a polynucleotide, an expression vector, a cell transfected with the expression vector, a method for screening an insulin resistance improving agent and a carbohydrate metabolism improving agent, and a method for producing a pharmaceutical composition are provided. The polypeptide is useful in screening an insulin resistance improving agent and a carbohydrate metabolism improving agent. When the polypeptide is overexpressed in a fat cell, the activity of Akt2 is reduced. Fat cells express the polypeptide. The polynucleotide encodes the polypeptide. The expression vector includes the polynucleotide. The screening method uses the polypeptide to screen for an insulin resistance improving agent and a carbohydrate metabolism improving agent. The production method uses the substance obtained by the screening method as the active ingredient of the pharmaceutical composition. The pharmaceutical composition is useful for insulin resistance improvement and carbohydrate metabolism improvement.
REFERENCES:
patent: 2003/0181366 (2003-09-01), Luo et al.
patent: 2003/0219741 (2003-11-01), Isogai et al.
patent: 1 293 569 (2003-03-01), None
patent: 2003-88388 (2003-03-01), None
Whiteman et al., Trends in Endocrinology & Metabolism, 2002, 13(10): 444-451.
Ngo et al., in The Protein Folding Problem and Tertiary Structure Prediction, 1994, Merz et al. (ed.), Birkhauser, Boston, MA, pp. 433 and 492-495.
Yasuhiro Mitsuuchi, et al., “Identification of a chromosome 3p14.3-21.1 gene,APPL,encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2”, Oncogebe, 1999, pp. 4891-4898, vol. 18.
Endo Yuki
Endoh Hideki
Inabe Kazunori
Kato Miyuki
Ueda Yoshitaka
Astellas Pharma Inc.
Lee Jae W
Ramirez Delia M.
Sughrue & Mion, PLLC
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