Protein tyrosine phosphatase inhibitor

Details Protein tyrosine phosphatase inhibitor Protein tyrosine phosphatase inhibitor

2007-04-03

2007-04-03

Balasubramanian, Venkataraman (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S184000

Reexamination Certificate

active

10363914

ABSTRACT:
Use of a compound of formula (I):whereineach R, which are the same or different, is H or C1–C6alkyl, andX completes a ring which is a substituted triazine having one of the following formulae (II) to (IV):wherein R′ is H or C1–C6alkyl;or an enol tautomer of a compound of formula (I) in which any of the groups R or R′ is hydrogen;in the manufacture of a medicament for use as a protein tyrosine phosphatase (PTP) inhibitor. Formula (I) embraces 2-methylfervenulone, which can be produced by fermentation of a novel microbial strain. Fermentation of the said strain also produces novel precursors to 2-methylfervenulone having utility as prodrugs.

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