Protein tyrosine kinase, JAK3

Details Protein tyrosine kinase, JAK3 Protein tyrosine kinase, JAK3

1998-01-06

1999-06-29

Teng, Sally P.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435 691, 530350, C07K 14435, C12N 912

Patent

active

059167920

ABSTRACT:
A novel protein tyrosine kinase, JAK3, and a polynucleotide sequence encoding JAK3 polypeptide are disclosed herein. JAK3 is a new member of the JAK family of protein tyrosine kinases which are important in regulation of cellular proliferation and differentiation. Also disclosed are therapeutic methods utilizing JAK3 polypeptide and polynucleotide sequences.

REFERENCES:
Witthuhn et al., "Involvement of the JAK-3 Janus kinase in signaling by interleukins 2 and 4 in lymphoid and myeloid cells," Nature, 370:153, Jul. 14, 1994.
Takamune et al., "Molecular cloning of rat JAK3, a novel member of the Jak family of protein tyrosine kinases," FEBS Letters (13847), 342:124, 1994.
Kawamura et al., "Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes," Proc. Natl. Acad. Sci. USA, 91:6374, Jul. 1994.
Lai et al., "A Kinase-deficient Splice Variant of the Human JAK3 is Expressed in Hematopoietic and Epithelial Cancer Cells", The Journal of Biological Chemistry, 270(42):25028, 1995.
Silvennoinen, "Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction", Proc. Natl. Acad. Sci, vol. 90, pp. 8429-8433, 1993.
Sambrook et al., "Expression of Cloned Genes in Cultured Mammalian Cells", Molecular Cloning, A Laboratory Manual Second Edition, 1989, Cold Spring Harbor Laboratory Press, CSH.

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